ReviewBritish journal of cancer1988
Recessive mechanisms of malignancy.
Review in British journal of cancer, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 56 citations in OpenAlex.
- A rationalized definition of general tumor suppressor microRNAs excludes miR-34a.Nucleic acids research · 2022Article
- Genetic alterations on chromosome 17 in human breast cancer: relationships to clinical features and DNA ploidy.Breast cancer research and treatment · 1993Article
- Congenital abnormalities in children with cancer and their relatives: results from a case-control study (IRESCC).British journal of cancer · 1993Article
- Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma.British journal of cancer · 1992Article
- Functional in vitro assays for the isolation of cell transformation effector and suppressor genes.Environmental health perspectives · 1991Review
- Alterations of oncogenes in metastatic tumours of human gastric carcinomas.British journal of cancer · 1990Article
- Cytogenetic abnormalities in cancer: with special emphasis on tumor heterogeneity.Cancer metastasis reviews · 1990Review
- Mutator phenotype of Werner syndrome is characterized by extensive deletions.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Adenocarcinoma and carcinoid developing spontaneously in the stomach of mutant strains of Mastomys natalensis.Virchows Archiv. A, Pathological anatomy and histopathology · 1989Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is increasingly recognised that recessive mutations play an important role in the pathogenesis of many forms of malignancy. Some of the affected loci may prove to be recessively-activated proto-oncogenes, but others are now known to be tumorigenic solely by virtue of their loss or inactivation and therefore form a distinct and novel family of tumour genes. Preliminary evidence suggests that such genes are likely to be functionally heterogeneous and to encode molecules involved in the inhibition of cellular proliferation and/or the induction of differentiation. Their further study is likely to illuminate fundamental mechanisms of normal cellular growth and differentiation as well as having important implications for the pathogenesis and management of cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.