Evidence map›Paper›PMID 30483251›Full record

ArticleFrontiers in immunology2018

Distinct Role of IL-27 in Immature and LPS-Induced Mature Dendritic Cell-Mediated Development of CD4

Fang Zhou, Guang-Xian Zhang, Abdolmohamad Rostami

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Biologic Agents in Crohn's Patients Reduce CD4Canadian journal of gastroenterology & hepatology · 2022
    Article
  6. Review
  7. Interferon-Disease markers · 2022
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fang ZhouDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Guang-Xian ZhangDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Abdolmohamad RostamiDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA, United States.
Thomas Jefferson University · US

Funding

Mechanisms of GM-CSF effect in CNS autoimmune demyelinationR01AI124386 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI ROSTAMI, A.M. · 2017 to 2021
$1.9M
The role of IL-27 in iv tolerance in EAER01AI106026 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI ROSTAMI, A.M. · 2014 to 2018
$1.9M
NIAID NIH HHS R01 AI106026NIAID NIH HHS R01 AI124386
6 · The paper itself

Abstract

Interleukin-27 (IL-27) plays an important role in regulation of anti-inflammatory responses and autoimmunity; however, the molecular mechanisms of IL-27 in modulation of immune tolerance and autoimmunity have not been fully elucidated. Dendritic cells (DCs) play a central role in regulating immune responses mediated by innate and adaptive immune systems, but regulatory mechanisms of DCs in CD4

Indexed as

AnimalsAntigens, SurfaceAutoimmunityCD4-Positive T-LymphocytesDendritic CellsEncephalomyelitis, Autoimmune, ExperimentalFemaleImmune ToleranceInterleukin-7 Receptor alpha SubunitInterleukinsLipopolysaccharidesMiceMice, Inbred C57BLMultiple SclerosisT-Lymphocytes, Regulatoryantigen 3G11, mouseAntigens, SurfaceIl27 protein, mouseInterleukin-7 Receptor alpha SubunitInterleukinsLipopolysaccharidesdendritic cellIL-27immune toleranceimmunotherapyregulatory T cell

Identifiers

PMID30483251
PMCPMC6244609
OpenAlexW2900859169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.