Evidence map›Paper›PMID 30483152›Full record

ArticleFrontiers in physiology2018

Effects of Acute Cold Stress After Long-Term Cold Stimulation on Antioxidant Status, Heat Shock Proteins, Inflammation and Immune Cytokines in Broiler Heart.

Haidong Wei, Runxiang Zhang, Yingying Su, Yanju Bi, Xiang Li, Xin Zhang, Jianhong Li, Jun Bao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 112 citations in OpenAlex.

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  8. Abiotic stressors in poultry production: A comprehensive review.Journal of animal physiology and animal nutrition · 2025
    Review
  9. Article
  10. Article
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  13. Article
  14. Heat Shock Protein Response to Stress in Poultry: A Review.Animals : an open access journal from MDPI · 2023
    Review
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Haidong WeiCollege of Life Science, Northeast Agricultural University, Harbin, China.
Runxiang ZhangCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, China.
Yingying SuCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, China.
Yanju BiCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, China.
Xiang LiCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, China.
Xin ZhangCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, China.
Jianhong LiCollege of Life Science, Northeast Agricultural University, Harbin, China.
Jun BaoCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, China.
Northeast Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the effects of acute cold stress (ACS) on chicken heart after cold stimulation, female broilers were raised in either normal (C) or gradually decreasing temperatures (CS I and CS II) for 34 days followed by a 24 h ACS at 7°C. Cardiac tissues were collected from the pre-ACS and ACS time points to analyze the histopathological changes, antioxidant status and the expression of heat shock proteins, inflammatory factors and immune-related cytokines. The CS II heart tissues showed shrunken cell membranes and nuclei, disordered or ruptured myocardial fibers, higher MDA content and upregulation in HSP27, HSP40, HSP70, NF-κB, COX-2, PTGEs, iNOS, TNF-α and IL-4 mRNAs, and in protein levels of HSP40, NF-κB and iNOS and reduction in CAT, GSH-px and SOD activity, as well as HSP90 and IFN-γ levels compared to the control tissues before ACS. In contrast, the HSPs were significantly increased, and the inflammatory and immune related factors were unaltered prior to the ACS in the CS I compared to the C group. Following ACS, MDA content was significantly increased and antioxidant activity was significantly decreased in the CS I and CS II groups compared to the C group. The levels of HSP27, HSP70, HSP90, inflammatory factors and IL-4 were significantly reduced and that of IFN-γ was significantly increased in CS I broiler hearts; the reverse trends were seen in CS II relative to CS I. Compared to the pre-ACS levels, that of HSP27, HSP40, HSP60, inflammatory factors and IL-4 were increased and IFN-γ was decreased in the C and CS II groups after ACS. Therefore, cold stimulation at drastically lower temperatures induced cardiac damage, which was further aggravated by ACS. In contrast, cold stimulation at only 3°C lower than normal temperature improved the adaptability of the broilers to ACS.

Indexed as

antioxidant statusbroiler heartcold stimulationheat shock proteinsimmune cytokinesinflammatory factors

Identifiers

PMID30483152
PMCPMC6243113
OpenAlexW2901826457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.