ReviewFrontiers in aging neuroscience2018
Can Blood Oxygenation Level Dependent Functional Magnetic Resonance Imaging Be Used Accurately to Compare Older and Younger Populations? A Mini Literature Review.
Review in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Transferability and sustainability of process-based multi-task adaptive cognitive training in community-dwelling older adults with mild cognitive impairment: a randomized controlled trial.BMC psychiatry · 2023Trial
- Integrating computational modeling, neuroimaging, and neuromodulation to decompose perceptual decision-making in healthy aging: a review of methods, findings, and gaps.Frontiers in aging neuroscience · 2026Review
- Systematic fMRI signal differences across cohorts alter lifespan trajectories of functional brain networks.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Evaluating Models of the Ageing BOLD Response.Human brain mapping · 2024Article
- Single-value scores of memory-related brain activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging.Human brain mapping · 2023Article
- Widespread fMRI BOLD Signal Overactivations during Cognitive Control in Older Adults Are Not Matched by Corresponding Increases in fPET Glucose Metabolism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins.Aging and disease · 2022Article
- Neuroimaging Modalities in Alzheimer's Disease: Diagnosis and Clinical Features.International journal of molecular sciences · 2022Review
- Age-related alterations in the cerebrovasculature affect neurovascular coupling and BOLD fMRI responses: Insights from animal models of aging.Psychophysiology · 2021Article
- Age-related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review.Psychophysiology · 2021Review
- Inhibition of emotions in healthy aging: age-related differences in brain network connectivity.Brain and behavior · 2021Article
- Investigating the effects of healthy cognitive aging on brain functional connectivity using 4.7 T resting-state functional magnetic resonance imaging.Brain structure & function · 2021Review
- Age-Related Compensatory Reconfiguration of PFC Connections during Episodic Memory Retrieval.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Is There Any Relationship Between Biochemical Indices and Anthropometric Measurements With Dorsolateral Prefrontal Cortex Activation Among Older Adults With Mild Cognitive Impairment?Frontiers in human neuroscience · 2021Article
- Age-related alterations in functional connectivity along the longitudinal axis of the hippocampus and its subfields.Hippocampus · 2021Article
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- Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans.GeroScience · 2019Review
- Changes in Resting-State Functional Connectivity of the Hippocampus Following Cognitive Effort Predict Memory Decline at Older Age-A Longitudinal fMRI Study.Frontiers in aging neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
A wealth of research has investigated the aging brain using blood oxygenation level dependent functional MRI [Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI)]. However, many studies do not consider the aging of the cerebrovascular system, which can influence the BOLD signal independently from neural activity, limiting what can be inferred when comparing age groups. Here, we discuss the ways in which the aging neurovascular system can impact BOLD fMRI, the consequences for age-group comparisons and possible strategies for mitigation. While BOLD fMRI is a valuable tool in this context, this review highlights the importance of consideration of vascular confounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.