Evidence map›Paper›PMID 30483038›Full record

ArticleCase reports in gastroenterology

Anti-TNF Exposure during Pregnancy in Crohn's Disease Patients.

Elen Farinelli de Campos Silva, Júlio Pinheiro Baima, Jaqueline Ribeiro de Barros, Fernanda Lofiego Renosto, Carina de Fatima de Sibia, Rogério Saad-Hossne, Ligia Yukie Sassaki

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elen Farinelli de Campos SilvaMedical School, Department of Internal Medicine, São Paulo State University (UNESP), Botucatu, Brazil.
Júlio Pinheiro BaimaMedical School, Department of Internal Medicine, São Paulo State University (UNESP), Botucatu, Brazil.
Jaqueline Ribeiro de BarrosMedical School, Department of Internal Medicine, São Paulo State University (UNESP), Botucatu, Brazil.
Fernanda Lofiego RenostoMedical School, Department of Internal Medicine, São Paulo State University (UNESP), Botucatu, Brazil.
Carina de Fatima de SibiaMedical School, Department of Surgery, São Paulo State University (UNESP), Botucatu, Brazil.
Rogério Saad-HossneMedical School, Department of Surgery, São Paulo State University (UNESP), Botucatu, Brazil.
Ligia Yukie SassakiMedical School, Department of Internal Medicine, São Paulo State University (UNESP), Botucatu, Brazil.
Universidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) affects young people of reproductive age. Therefore, a broad discussion is needed about the possible disease effects in pregnancy, as well as the risks of fetal exposure to the medications used, especially biological therapy. This study aimed to describe the management of 4 Crohn's disease patients who received anti-TNF therapy during pregnancy and present a literature review. We reported 4 cases composed of young women who became pregnant while receiving anti-TNF agents. The patients presented a satisfactory response to the clinical treatment and the pregnancies progressed without complications. We did not observe maternal or embryonic toxicity, or unfavorable outcomes. The available data point to inflammatory activity as the main risk factor for unfavorable gestational evolution to date, and showed anti-TNF therapy to be safe during pregnancy and breastfeeding. However, the benefits and risks must be discussed with the patient and management decisions should be taken on an individual basis.

Indexed as

Anti-TNF therapyBiological therapyCrohn's diseaseInflammatory bowel diseasePregnancy

Identifiers

PMID30483038
PMCPMC6244106
OpenAlexW2896242916

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.