Evidence map›Paper›PMID 30482948›Full record

ArticleNature neuroscience2018

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.

Raymond K Walters, Renato Polimanti, Emma C Johnson, Jeanette N McClintick, Mark J Adams, Amy E Adkins, Fazil Aliev, Silviu-Alin Bacanu, Anthony Batzler, Sarah Bertelsen and 158 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 406 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
406citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

406 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Review
  12. Article
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346 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

168 authors.

Raymond K WaltersAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8422-6530
Renato PolimantiDepartment of Psychiatry, Yale School of Medicine and Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA.
Emma C JohnsonWashington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.
Jeanette N McClintickDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Mark J AdamsUniversity of Edinburgh, Division of Psychiatry, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3599-6018
Amy E AdkinsDepartment of Psychology & College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, VA, USA.
Fazil AlievVirginia Commonwealth University, Department of Psychology, Richmond, VA, USA.
Silviu-Alin BacanuVirginia Commonwealth University Alcohol Research Center; Virginia Institute for Psychiatric and Behavioral Genetics; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Anthony BatzlerMayo Clinic, Psychiatric Genomics and Pharmacogenomics Program, Rochester, MN, USA.
Sarah BertelsenIcahn School of Medicine at Mount Sinai, Department of Neuroscience, New York, NY, USA.
Joanna M BiernackaMayo Clinic, Department of Health Sciences Research, and Department of Psychiatry and Psychology, Rochester, MN, USA.
Tim B BigdeliDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
Li-Shiun ChenWashington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.
Toni-Kim ClarkeUniversity of Edinburgh, Division of Psychiatry, Edinburgh, UK.
Yi-Ling ChouWashington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.
Franziska DegenhardtInstitute of Human Genetics, University of Bonn; and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
Anna R DochertyUniversity of Utah, Department of Psychiatry, Salt Lake City, UT, USA.
Alexis C EdwardsVirginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA.
Pierre Fontanillas23andMe, Inc, Mountain View, CA, USA.ORCID http://orcid.org/0000-0002-8944-4454
Jerome C FooDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Louis FoxWashington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.
Josef FrankDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-4867-9465
Ina GieglingMartin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics, Halle, Germany.
Scott GordonQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Laura M HackDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Annette M HartmannMartin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics, Halle, Germany.
Sarah M HartzWashington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.
Stefanie Heilmann-HeimbachInstitute of Human Genetics, University of Bonn; and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
Stefan HermsInstitute of Human Genetics, University of Bonn; and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-2786-8200
Colin HodgkinsonNIH/NIAAA, Laboratory of Neurogenetics, Bethesda, MD, USA.
Per HoffmannInstitute of Human Genetics, University of Bonn; and Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
Jouke Jan HottengaDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Martin A KennedyUniversity of Otago, Christchurch, New Zealand.ORCID http://orcid.org/0000-0002-6445-8526
Mervi Alanne-KinnunenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Bettina KonteMartin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics, Halle, Germany.ORCID http://orcid.org/0000-0001-5287-308X
Jari LahtiHelsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland.
Marius Lahti-PulkkinenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-5244-5525
Dongbing LaiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0001-7803-580X
Lannie LigthartDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Anu LoukolaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Brion S MaherJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Hamdi MbarekDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1108-0371
Andrew M McIntoshUniversity of Edinburgh, Division of Psychiatry, Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0198-4588
Matthew B McQueenDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Jacquelyn L MeyersHenri Begleiter Neurodynamics Laboratory, Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Yuri MilaneschiDepartment of Psychiatry, Amsterdam Public Health Research Institute, VU University Medical Center/GGz inGeest, Amsterdam, The Netherlands.
Teemu PalviainenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-7847-8384
John F PearsonBiostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand.
Roseann E PetersonVirginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA.
Samuli RipattiAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Euijung RyuMayo Clinic, Department of Health Sciences Research, Rochester, MN, USA.
Nancy L SacconeWashington University School of Medicine, Department of Genetics, St. Louis, MO, USA.
Jessica E SalvatoreVirginia Commonwealth University, Department of Psychology, Richmond, VA, USA.
Sandra Sanchez-RoigeUniversity of California San Diego, Department of Psychiatry, San Diego, CA, USA.
Melanie SchwandtNIH/NIAAA, Office of the Clinical Director, Bethesda, MD, USA.
Richard ShervaDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-1080-4339
Jana StrohmaierDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Nathaniel ThomasDepartment of Psychology & College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, VA, USA.
Jen-Chyong WangIcahn School of Medicine at Mount Sinai, Department of Neuroscience, New York, NY, USA.
Bradley T WebbVirginia Commonwealth University Alcohol Research Center; Virginia Institute for Psychiatric and Behavioral Genetics; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Robbee WedowAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3108-7087
Leah WetherillDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Amanda G WillsUniversity of Colorado School of Medicine, Department of Pharmacology, Aurora, CO, USA.
23andMe Research Team
Jason D BoardmanInstitute of Behavioral Science and Department of Sociology, University of Colorado, Boulder, CO, USA.
Danfeng ChenStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Doo-Sup ChoiMayo Clinic, Department of Molecular Pharmacology and Experimental Therapeutics, Rochester, MN, USA.
William E CopelandDuke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA.
Robert C CulverhouseWashington University School of Medicine, Department of Medicine and Division of Biostatistics, St. Louis, MO, USA.
Norbert DahmenDepartment of Psychiatry, University of Mainz, Mainz, Germany.
Louisa DegenhardtNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia.
Benjamin W DomingueStanford University Graduate School of Education, Stanford, CA, USA.
Sarah L Elson23andMe, Inc, Mountain View, CA, USA.
Mark A FryeMayo Clinic, Department of Psychiatry and Psychology, Rochester, MN, USA.
Wolfgang GäbelDepartment of Psychiatry and Psychotherapy, University of Düsseldorf, Düsseldorf, Germany.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9405-9550
Marcus IsingMax-Planck-Institute of Psychiatry, Munich, Germany.
Margaret KeyesUniversity of Minnesota, Department of Psychology, Minneapolis, MN, USA.
Falk KieferDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
John KramerUniversity of Iowa Roy J and Lucille A Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-1321-7087
Samuel KupermanUniversity of Iowa Roy J and Lucille A Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA.
Susanne LucaeMax-Planck-Institute of Psychiatry, Munich, Germany.
Michael T LynskeyAddictions Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Wolfgang MaierDepartment of Psychiatry, University of Bonn, Bonn, Germany.
Karl MannDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Satu MännistöInstitute for Health and Welfare, Helsinki, Finland.
Bertram Müller-MyhsokDepartment of Statistical Genetics, Max-Planck-Institute of Psychiatry, Munich, Germany.
Alison D MurrayThe Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.
John I NurnbergerDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Aarno PalotieAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ulrich PreussMartin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics, Halle, Germany.
Katri RäikkönenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Maureen D ReynoldsUniversity of Pittsburgh, School of Pharmacy, Pittsburgh, PA, USA.
Monika RidingerDepartment of Psychiatry and Psychotherapy, University of Regensburg Psychiatric Health Care Aargau, Regensburg, Germany.
Norbert ScherbaumLVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Department of Addictive Behaviour and Addiction Medicine, Medical Faculty, University of Duisburg-Essen, Duisburg, Germany.
Marc A SchuckitUniversity of California San Diego, Department of Psychiatry, San Diego, CA, USA.
Michael SoykaMedical Park Chiemseeblick in Bernau-Felden, Chiemsee, Germany.
Jens TreutleinDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Stephanie WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0002-1571-1468
Norbert WodarzDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Peter ZillPsychiatric Hospital, Ludwig-Maximilians-University, Munich, Germany.
Daniel E AdkinsUniversity of Utah, Department of Psychiatry, Salt Lake City, UT, USA.
Joseph M BodenUniversity of Otago, Christchurch, New Zealand.
Dorret I BoomsmaDepartment of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Laura J BierutWashington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.
Sandra A BrownUniversity of California San Diego, Department of Psychiatry, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-8780-0323
Kathleen K BucholzWashington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.
Sven CichonHuman Genomics Research Group, Department of Biomedicine, University of Basel Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
E Jane CostelloDuke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA.
Harriet de WitNIAAA Intramural Research Program, Bethesda, MD, USA.
Nancy DiazgranadosNIAAA Intramural Research Program, Bethesda, MD, USA.
Danielle M DickDepartment of Psychology & College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, VA, USA.
Johan G ErikssonDepartment of General Practice and Primary Health Care, University of Helsinki, and National Institute for Health and Welfare, Helsinki, Finland.
Lindsay A FarrerDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Nathan A GillespieVirginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA.
Alison M GoateIcahn School of Medicine at Mount Sinai, Department of Neuroscience, New York, NY, USA.ORCID http://orcid.org/0000-0002-0576-2472
David GoldmanNIH/NIAAA, Laboratory of Neurogenetics, Bethesda, MD, USA.
Richard A GruczaWashington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.
Dana B HancockCenter for Omics Discovery and Epidemiology, Behavioral Health Research Division, RTI International, Research Triangle Park, NC, USA.
Kathleen Mullan HarrisDepartment of Sociology and Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Andrew C HeathWashington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.
Victor HesselbrockUniversity of Connecticut School of Medicine, Department of Psychiatry, Farmington, CT, USA.
John K HewittUniversity of Colorado Boulder, Institute for Behavioral Genetics, Boulder, CO, USA.
Christian J HopferUniversity of Colorado Denver, School of Medicine, Denver, CO, USA.
John HorwoodUniversity of Otago, Christchurch, New Zealand.
William IaconoUniversity of Minnesota, Department of Psychology, Minneapolis, MN, USA.
Eric O JohnsonRTI International, Fellows Program, Research Triangle Park, NC, USA.
Jaakko A KaprioInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3716-2455
Victor M KarpyakMayo Clinic, Department of Psychiatry and Psychology, Rochester, MN, USA.
Kenneth S KendlerVirginia Commonwealth University Alcohol Research Center; Virginia Institute for Psychiatric and Behavioral Genetics; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Henry R KranzlerUniversity of Pennsylvania Perelman School of Medicine, Center for Studies of Addiction, Department of Psychiatry and VISN 4 MIRECC, Crescenz VAMC, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1018-0450
Kenneth KrauterUniversity of Colorado Boulder, Department of Molecular, Cellular, and Developmental Biology, Boulder, CO, USA.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Instituet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-3037-5287
Penelope A LindQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-3887-2598
Matt McGueUniversity of Minnesota, Department of Psychology, Minneapolis, MN, USA.
James MacKillopPeter Boris Centre for Addictions Research, McMaster University/St. Joseph's Healthcare Hamilton; Michael G. DeGroote Centre for Medicinal Cannabis Research, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-4118-9500
Pamela A F MaddenWashington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.
Hermine H MaesVirginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA.
Patrik MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Instituet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7315-7899
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-1382-380X
Grant W MontgomeryThe Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-4140-8139
Elliot C NelsonWashington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.
Markus M NöthenInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
Abraham A PalmerUniversity of California San Diego, Department of Psychiatry, San Diego, CA, USA.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Instituet, Stockholm, Sweden.
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam Public Health Research Institute, VU University Medical Center/GGz inGeest, Amsterdam, The Netherlands.
Bernice PorjeszHenri Begleiter Neurodynamics Laboratory, Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.
John P RiceWashington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0002-5236-6149
Brien P RileyVirginia Commonwealth University Alcohol Research Center; Virginia Institute for Psychiatric and Behavioral Genetics; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Richard RoseDepartment of Psychological & Brain Sciences, Indiana University Bloomington, Bloomington, IN, USA.
Dan RujescuMartin-Luther-University Halle-Wittenberg, Department of Psychiatry, Psychotherapy and Psychosomatics, Halle, Germany.
Pei-Hong ShenNIH/NIAAA, Laboratory of Neurogenetics, Bethesda, MD, USA.
Judy SilbergVirginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA.
Michael C StallingsUniversity of Colorado Boulder, Institute for Behavioral Genetics, Boulder, CO, USA.
Ralph E TarterUniversity of Pittsburgh, School of Pharmacy, Pittsburgh, PA, USA.
Michael M VanyukovUniversity of Pittsburgh, School of Pharmacy, Pittsburgh, PA, USA.
Scott VriezeUniversity of Minnesota, Department of Psychology, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-3861-7930
Tamara L WallUniversity of California San Diego, Department of Psychiatry, San Diego, CA, USA.
John B WhitfieldQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-1103-0876
Hongyu ZhaoDepartment of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA.
Benjamin M NealeAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1513-6077
Joel GelernterDepartments of Psychiatry, Genetics, and Neuroscience, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, USA. joel.gelernter@yale.edu.ORCID http://orcid.org/0000-0002-4067-1859
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. edenberg@iu.edu.ORCID http://orcid.org/0000-0003-0344-9690
Arpana AgrawalWashington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA. Arpana@wustl.edu.ORCID http://orcid.org/0000-0002-0313-793X

Funding

NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7M
Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1M
Integrative genetics of behavior with high throughput technologiesZIAAA000301 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GOLDMAN, DAVID · 2009 to 2025
$68.6M
NIAAA Repository/Screening Database Management and ResearchZIAAA000130 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI SCHWANDT, MELANIE · 2017 to 2025
$60.1M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Sequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI PALMER, ABRAHAM A · 2014 to 2023
$27.4M
TRANSLATION MODULEP50DA005605 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RIDENOUR, TY A · 1989 to 2014
$25.7M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
Twin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5M
TRANSLATION AND DISSEMINATION COREP30DA023026 · NIDA · DUKE UNIVERSITY · PI HOYLE, RICK · 2008 to 2023
$19.6M
Project 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MICHAEL F MILES · 2014 to 2026
$19.6M
AHRQ HHS R18 HS024208EPA EP-C-15-001Medical Research Council MR/K026992/1NCATS NIH HHS UL1 TR000135NCI NIH HHS P01 CA089392NCRR NIH HHS UL1 RR031990NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS N01 HG065403NHGRI NIH HHS R01 HG008983NHGRI NIH HHS U01 HG004422NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NIAAA NIH HHS K01 AA021399NIAAA NIH HHS K01 AA024152NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P20 AA017828NIAAA NIH HHS P20 AA017830NIAAA NIH HHS P50 AA011998NIAAA NIH HHS P50 AA022537NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA007728NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA009367NIAAA NIH HHS R01 AA011330NIAAA NIH HHS R01 AA011408NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA014041NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R01 AA017444NIAAA NIH HHS R01 AA017535NIAAA NIH HHS R01 AA018779NIAAA NIH HHS R21 AA022717NIAAA NIH HHS R21 AA024888NIAAA NIH HHS R21 AA025214NIAAA NIH HHS R37 AA007728NIAAA NIH HHS R37 AA009367NIAAA NIH HHS R37 AA011408NIAAA NIH HHS R37 AA012502NIAAA NIH HHS T32 AA007464NIAAA NIH HHS U10 AA008401NICHD NIH HHS P01 HD031921NICHD NIH HHS P2C HD050924NICHD NIH HHS P2C HD066613NICHD NIH HHS R01 HD042157NICHD NIH HHS R01 HD060726NICHD NIH HHS R01 HD073342NICHD NIH HHS R01 HD093651NIDA NIH HHS K01 DA037914NIDA NIH HHS K02 DA032573NIDA NIH HHS K08 DA019951NIDA NIH HHS K08 DA032680NIDA NIH HHS K24 DA032555NIDA NIH HHS P30 DA023026NIDA NIH HHS P50 DA005605NIDA NIH HHS P50 DA037844NIDA NIH HHS P60 DA011015NIDA NIH HHS R00 DA023549NIDA NIH HHS R01 DA002812NIDA NIH HHS R01 DA005147NIDA NIH HHS R01 DA011301NIDA NIH HHS R01 DA012690NIDA NIH HHS R01 DA012845NIDA NIH HHS R01 DA012849NIDA NIH HHS R01 DA012854NIDA NIH HHS R01 DA013240NIDA NIH HHS R01 DA013423NIDA NIH HHS R01 DA016977NIDA NIH HHS R01 DA017305NIDA NIH HHS R01 DA018432NIDA NIH HHS R01 DA019157NIDA NIH HHS R01 DA019963NIDA NIH HHS R01 DA021905NIDA NIH HHS R01 DA021913NIDA NIH HHS R01 DA024413NIDA NIH HHS R01 DA024417NIDA NIH HHS R01 DA025109NIDA NIH HHS R01 DA035804NIDA NIH HHS R01 DA036216NIDA NIH HHS R01 DA036523NIDA NIH HHS R01 DA036525NIDA NIH HHS R01 DA036583NIDA NIH HHS R01 DA036628NIDA NIH HHS R01 DA037904NIDA NIH HHS R01 DA038076NIDA NIH HHS R01 DA039408NIDA NIH HHS R01 DA042620NIDA NIH HHS R01 DA042755NIDA NIH HHS R01 DA044014NIDA NIH HHS R01 DA046436NIDA NIH HHS R21 DA040177NIDA NIH HHS R21 DA041883NIDA NIH HHS R21 DA043735NIDA NIH HHS R25 DA027995NIDA NIH HHS R33 DA041883NIDA NIH HHS R37 DA005147NIDA NIH HHS R56 DA012854NIDA NIH HHS RC2 DA028909NIDA NIH HHS U01 DA024413NIDA NIH HHS U01 DA024417NIDDK NIH HHS U01 DK066134NIMH NIH HHS K01 MH093731NIMH NIH HHS K01 MH109765NIMH NIH HHS K01 MH113848NIMH NIH HHS K23 MH080230NIMH NIH HHS R01 MH048085NIMH NIH HHS R01 MH063671NIMH NIH HHS R01 MH063970NIMH NIH HHS R01 MH066140NIMH NIH HHS R01 MH068521NIMH NIH HHS R01 MH077874NIMH NIH HHS R01 MH081802NIMH NIH HHS R01 MH083094NIMH NIH HHS R01 MH100549NIMH NIH HHS R01 MH107649NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS U01 MH094432NIMH NIH HHS U01 MH109532NIMH NIH HHS U01 MH109536NIMH NIH HHS U01 MH109539NIMH NIH HHS U24 MH068457Wellcome Trust
6 · The paper itself

Abstract

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case-control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, n = 46,568; African, n = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; P = 9.8 × 10

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAlcoholismAllelesGenome-Wide Association StudyGenotypeHumansMental DisordersPhenotype

Identifiers

PMID30482948
PMCPMC6430207

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