Trial reportInternational journal of obesity (2005)2019
Niacin induces miR-502-3p expression which impairs insulin sensitivity in human adipocytes.
Trial report in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01083329 (Effect of Nicotinic Acid on Adipose Tissue Inflammation in Obese Subjects), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Nicotinic Acid on Adipose Tissue Inflammation in Obese Subjects
Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Adipose Tissue Resistance to the Antilipolytic Effect of Insulin and Niacin in Humans With Obesity.Diabetes · 2026Article
- Article
- Specific GPCRs Elicit Unique Extracellular Vesicle MiRNA Array Signatures: An Exploratory Study.bioRxiv : the preprint server for biology · 2025Article
- Association between dietary niacin intake and benign prostatic hyperplasia: a population-based results from NHANES 2003-2008.Journal of health, population, and nutrition · 2024Article
- Relationship between dietary niacin intake and erectile dysfunction: a population-based study.Asian journal of andrology · 2024Article
- miRNAs as Interconnectors between Obesity and Cancer.Non-coding RNA · 2024Review
- Role of MicroRNA-502-3p in Human Diseases.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Hepatic transcript profiling in beef cattle: Effects of rumen-protected niacin supplementation.PloS one · 2023Article
- NADAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- The Related Metabolic Diseases and Treatments of Obesity.Healthcare (Basel, Switzerland) · 2022Review
- Effects of NAD+ precursor supplementation on glucose and lipid metabolism in humans: a meta-analysis.Nutrition & metabolism · 2022Article
- Review
- Cell-Free Biological Approach for Corneal Stromal Wound Healing.Frontiers in pharmacology · 2021Review
- The Effect of Vitamin Supplementation on Subclinical Atherosclerosis in Patients without Manifest Cardiovascular Diseases: Never-ending Hope or Underestimated Effect?Molecules (Basel, Switzerland) · 2020Review
- The Potential for microRNA Therapeutics and Clinical Research.Frontiers in genetics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs have been involved in insulin resistance (IR). As the mechanism whereby niacin, an anti-dyslipidemic agent, leads to IR remains elusive, we sought to identify differentially expressed microRNAs in adipose tissue (AT) of individuals receiving niacin and to explore the link between microRNAs, niacin and IR in human adipocytes.In a double-blind controlled study, 22 obese men received extended-release niacin or placebo over 8 weeks. Bioclinical data and subcutaneous AT biopsies were obtained before and after treatment. AT microRNA expression profiles were determined using RTqPCR for 758 human-specific microRNAs. hMADS adipocytes were treated with niacin, or acipimox (a niacin-like drug without effect on IR), or transfected with miR-502-3p. Glucose uptake and Western blotting were performed.In obese men, insulin sensitivity decreased after niacin treatment. In AT, the expression of 6 microRNAs including miR-502-3p was up-regulated. Treatment of hMADS adipocytes with niacin specifically increased miR-502-3p expression. Acipimox had no effect. Overexpression of miR-502-3p in adipocytes led to reduced insulin-induced glucose uptake and lower insulin-stimulated AKT phosphorylation.Long term niacin treatment altered microRNA expression levels in human AT. Increased miR-502-3p expression may play a role in the mediation of IR due to niacin in adipocytes.The study is registered in Clinical Trials NCT01083329 and EudraCT 2009-012124-85.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.