Evidence map›Paper›PMID 30482860›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

NETSeq reveals heterogeneous nucleotide incorporation by RNA polymerase I.

Andrew M Clarke, Krysta L Engel, Keith E Giles, Chad M Petit, David A Schneider

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andrew M ClarkeDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.
Krysta L EngelDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.
Keith E GilesDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.
Chad M PetitDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294 cpetit@uab.edu dschneid@uab.edu.
David A SchneiderDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294 cpetit@uab.edu dschneid@uab.edu.ORCID 0000-0003-0635-5091
University of Alabama at Birmingham · US

Funding

Control of RNA polymerase I transcription initiation and elongationR01GM084946 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHNEIDER, DAVID ALAN · 2009 to 2020
$3.8M
Strain Dependent Structure and Function of the Influenza NS1 ProteinR01AI134693 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PETIT, CHAD · 2018 to 2022
$1.9M
NIAID NIH HHS R01 AI134693NIGMS NIH HHS R01 GM084946
6 · The paper itself

Abstract

DNA sequence motifs that affect RNA polymerase transcription elongation are well studied in prokaryotic organisms and contribute directly to regulation of gene expression. Despite significant work on the regulation of eukaryotic transcription, the effect of DNA template sequence on RNA polymerase I (Pol I) transcription elongation remains unknown. In this study, we examined the effects of DNA sequence motifs on Pol I transcription elongation kinetics in vitro and in vivo. Specifically, we characterized how the

Indexed as

Transcription Elongation, GeneticBase SequenceConserved SequenceDNA, BacterialDNA, FungalDNA, RibosomalEscherichia coliEscherichia coli ProteinsPeriplasmic ProteinsPromoter Regions, GeneticRNA Polymerase ISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence Analysis, DNASpecies SpecificityTerminator Regions, GeneticDNA, BacterialDNA, FungalDNA, RibosomalEscherichia coli ProteinsPeriplasmic ProteinsRho protein, E coliRNA Polymerase ISaccharomyces cerevisiae ProteinsSpy protein, E coliUridine TriphosphateribosomeRNA polymerase Itranscription elongationtranscription pausingtranscription termination

Identifiers

PMID30482860
PMCPMC6294894
OpenAlexW2902424908

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.