Evidence map›Paper›PMID 30482850›Full record

ArticleScience signaling2018

Aspirin ameliorates experimental autoimmune encephalomyelitis through interleukin-11-mediated protection of regulatory T cells.

Susanta Mondal, Malabendu Jana, Sridevi Dasarathi, Avik Roy, Kalipada Pahan

Abstract read
In one paragraph

Article in Science signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

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  8. Build muscles and protect myelin.NeuroImmune pharmacology and therapeutics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Susanta MondalDivision of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA.
Malabendu JanaDivision of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA.
Sridevi DasarathiDivision of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA.ORCID 0000-0001-5915-0570
Avik RoyDivision of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA.
Kalipada PahanDivision of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA. kalipada_pahan@rush.edu.ORCID 0000-0001-6048-9598
Jesse Brown VA Medical Center · USRush University Medical Center · US

Funding

Cinnamon, CNTF and EAER01AT006681 · NCCIH · RUSH UNIVERSITY MEDICAL CENTER · PI PAHAN, KALIPADA · 2011 to 2015
$1.8M
Aspirin, PPAR and EAEI01BX002174 · VA · JESSE BROWN VA MEDICAL CENTER · PI PAHAN, KALIPADA · 2013 to 2016
–
BLRD VA I01 BX002174NCCIH NIH HHS R01 AT006681
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a human disease that results from autoimmune T cells targeting myelin protein that is expressed within the central nervous system. In MS, the number of FoxP3-expressing regulatory T cells (T

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalAspirinCells, CulturedCyclic AMP Response Element-Binding ProteinDose-Response Relationship, DrugEncephalomyelitis, Autoimmune, ExperimentalFemaleInterleukin-11MiceMice, Inbred C57BLPeptide FragmentsTh17 CellsTh1 CellsT-Lymphocytes, RegulatoryAnti-Inflammatory Agents, Non-SteroidalAspirinCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinInterleukin-11Peptide Fragments

Identifiers

PMID30482850
PMCPMC6325078
OpenAlexW2903465699

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.