Evidence map›Paper›PMID 30482832›Full record

ArticlemBio2018

Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response.

Ekansh Mittal, Michael L Skowyra, Grace Uwase, Emir Tinaztepe, Alka Mehra, Stefan Köster, Phyllis I Hanson, Jennifer A Philips

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 114 citations in OpenAlex.

  1. Study on the Role of Galectin-3 in Sepsis.Biochemical genetics · 2026
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  4. ThemBio · 2026
    Article
  5. Article
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  7. Review
  8. Control of antigen presentation on MHC-I by a bacterial secretion system.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Lysosomal Repair in Health and Disease.Journal of cellular physiology · 2025
    Review
  12. Protease shaving ofMicrobiology spectrum · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Comparative transcriptomic signatures of virulent and attenuatedFrontiers in cellular and infection microbiology · 2025
    Article
  18. Article
  19. Protease shaving ofbioRxiv : the preprint server for biology · 2024
    Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ekansh MittalDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Michael L SkowyraDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Grace UwaseDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Emir TinaztepeDivision of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, New York, USA.
Alka MehraDivision of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, New York, USA.
Stefan KösterDivision of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, New York, USA.
Phyllis I HansonDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Jennifer A PhilipsDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA philips.j.a@wustl.edu.
Washington University in St. Louis · USNew York University · US

Funding

THE ROLE OF ESCRT IN MACROPHAGE RESISTANCE TO MYCOBACTERIAR01AI087682 · NIAID · WASHINGTON UNIVERSITY · PI PHILIPS, JENNIFER A · 2011 to 2022
$4.9M
ANALYSIS OF ESCRT FUNCTION IN ENDOLYSOSOMAL TRAFFICKINGR01GM122434 · NIGMS · WASHINGTON UNIVERSITY · PI HANSON, PHYLLIS I · 2017 to 2024
$3.7M
NIAID NIH HHS R01 AI087682NIGMS NIH HHS R01 GM122434
6 · The paper itself

Abstract

Intracellular pathogens have varied strategies to breach the endolysosomal barrier so that they can deliver effectors to the host cytosol, access nutrients, replicate in the cytoplasm, and avoid degradation in the lysosome. In the case of

Indexed as

Host-Pathogen InteractionsAnimalsAntigens, BacterialBacterial ProteinsCell LineEndosomal Sorting Complexes Required for TransportHumansMiceMycobacterium tuberculosisPhagosomesProtein BindingType VII Secretion SystemsVirulence FactorsAntigens, BacterialBacterial ProteinsEndosomal Sorting Complexes Required for TransportESAT-6 protein, Mycobacterium tuberculosisType VII Secretion SystemsVirulence Factorsendomembrane damageESCRTMycobacterium tuberculosisphagosomestype VII secretion system

Identifiers

PMID30482832
PMCPMC6282207
OpenAlexW2902814816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.