Evidence map›Paper›PMID 30482766›Full record

GuidelineBlood advances2018

American Society of Hematology 2018 Guidelines for management of venous thromboembolism: treatment of pediatric venous thromboembolism.

Paul Monagle, Carlos A Cuello, Caitlin Augustine, Mariana Bonduel, Leonardo R Brandão, Tammy Capman, Anthony K C Chan, Sheila Hanson, Christoph Male, Joerg Meerpohl and 12 more

Abstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Paul MonagleDepartment of Clinical Haematology, Royal Children's Hospital, University of Melbourne and Murdoch Children's Research Institute, VIC, Australia.
Carlos A CuelloDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-1742-0242
Caitlin AugustineBoston, MA.
Mariana BonduelDepartment of Hematology/Oncology, Hospital de Pediatria "Prof. Dr. Juan P. Garrahan," Buenos Aires, Argentina.
Leonardo R BrandãoDivision of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Tammy CapmanMelbourne, FL.
Anthony K C ChanDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Sheila HansonDepartment of Pediatrics, Medical College of Wisconsin and Critical Care Section, Children's Hospital of Wisconsin, Milwaukee, WI.
Christoph MaleDepartment of Pediatrics, Medical University of Vienna, Vienna, Austria.
Joerg MeerpohlDepartment of Medical Biometry and Statistics, Institute of Medical Biometry and Medical Informatics, University of Freiburg and University Medical Center Freiburg, Freiburg, Germany.
Fiona NewallDepartment of Clinical Haematology and.
Sarah H O'BrienDivision of Pediatric Hematology/Oncology, Nationwide Children's Hospital, The Ohio State University, Columbus, OH.
Leslie RaffiniDepartment of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA.
Heleen van OmmenDepartment of Pediatric Hematology, Sophia Children's Hospital Erasmus MC, Rotterdam, The Netherlands.
John WiernikowskiDivision of Hematology/Oncology, Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
Suzan WilliamsDepartment of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Meha BhattDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
John J RivaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Yetiani RoldanDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Nicole SchwabDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Reem A MustafaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Sara K VeselyDepartment of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK.ORCID 0000-0003-3448-0156

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite an increasing incidence of venous thromboembolism (VTE) in pediatric patients in tertiary care settings, relatively few pediatric physicians have experience with antithrombotic interventions.

objectiveThese guidelines of the American Society of Hematology (ASH), based on the best available evidence, are intended to support patients, clinicians, and other health care professionals in their decisions about management of pediatric VTE.

methodsASH formed a multidisciplinary guideline panel that included 2 patient representatives and was balanced to minimize potential bias from conflicts of interest. The McMaster University GRADE Centre supported the guideline-development process, including updating or performing systematic evidence reviews (up to April of 2017). The panel prioritized clinical questions and outcomes according to their importance for clinicians and patients. The panel used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach, including GRADE Evidence-to-Decision frameworks, to assess evidence and make recommendations, which were subject to public comment.

resultsThe panel agreed on 30 recommendations, covering symptomatic and asymptomatic deep vein thrombosis, with specific focus on management of central venous access device-associated VTE. The panel also addressed renal and portal vein thrombosis, cerebral sino venous thrombosis, and homozygous protein C deficiency.

conclusionsAlthough the panel offered many recommendations, additional research is required. Priorities include understanding the natural history of asymptomatic thrombosis, determining subgroup boundaries that enable risk stratification of children for escalation of treatment, and appropriate study of newer anticoagulant agents in children.

Indexed as

AnticoagulantsAntithrombinsCentral Venous CathetersChildEvidence-Based MedicineHumansPortal VeinPulmonary EmbolismPurpura FulminansRenal VeinsRisk FactorsVenous ThromboembolismVenous ThrombosisAnticoagulantsAntithrombins

Identifiers

PMID30482766
PMCPMC6258911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.