Evidence map›Paper›PMID 30482765›Full record

GuidelineBlood advances2018

American Society of Hematology 2018 guidelines for management of venous thromboembolism: optimal management of anticoagulation therapy.

Daniel M Witt, Robby Nieuwlaat, Nathan P Clark, Jack Ansell, Anne Holbrook, Jane Skov, Nadine Shehab, Juliet Mock, Tarra Myers, Francesco Dentali and 7 more

Open access · goldAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 232 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
232citing papers in PubMed, 22 pooled it
48.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

232 citing papers in PubMed, 22 syntheses or guidelines pooled it, 492 citations in OpenAlex.

  1. Pooled it
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  3. Guideline
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  7. Therapeutic Enoxaparin Dosing in Obesity.The Annals of pharmacotherapy · 2025
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  11. Direct oral anticoagulants for venous thromboembolism in cancer patients: a systematic review and network meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
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  13. Guideline
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  16. Guideline
  17. Guideline
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  19. Hematological findings and complications of COVID-19.American journal of hematology · 2020
    Pooled it
  20. Guideline

172 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 4 countries.

Daniel M WittDepartment of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City, UT.
Robby NieuwlaatDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Nathan P ClarkClinical Pharmacy Anticoagulation and Anemia Service, Kaiser Permanente Colorado, Aurora, CO.
Jack AnsellSchool of Medicine, Hofstra Northwell, Hempstead, NY.
Anne HolbrookDivision of Clinical Pharmacology and Toxicology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Jane SkovUnit for Health Promotion Research, Department of Public Health, University of Southern Denmark, Esbjerg, Denmark.
Nadine ShehabDivision of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA.
Juliet MockAurora Medical Center Summit, Summit, WI.
Tarra MyersCambridge, ON, Canada.
Francesco DentaliDepartment of Medicine and Surgery, Insubria University, Varese, Italy.
Mark A CrowtherDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Arnav AgarwalDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-0931-7851
Meha BhattDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Rasha KhatibDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL; and.
John J RivaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Yuan ZhangDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-4174-0641
Gordon GuyattDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Impact · CAMcMaster University · CAAurora Medical Center · USCenters for Disease Control and Prevention · USHofstra University · USKaiser Permanente · USNorthwestern University · USUniversity of Insubria · ITUniversity of Southern Denmark · DKUniversity of Toronto · CAUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinicians confront numerous practical issues in optimizing the use of anticoagulants to treat venous thromboembolism (VTE).

objectiveThese evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians and other health care professionals in their decisions about the use of anticoagulants in the management of VTE. These guidelines assume the choice of anticoagulant has already been made.

methodsASH formed a multidisciplinary guideline panel balanced to minimize potential bias from conflicts of interest. The McMaster University GRADE Centre supported the guideline development process, including updating or performing systematic evidence reviews. The panel prioritized clinical questions and outcomes according to their importance for clinicians and patients. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess evidence and make recommendations, which were subject to public comment.

resultsThe panel agreed on 25 recommendations and 2 good practice statements to optimize management of patients receiving anticoagulants.

conclusionsStrong recommendations included using patient self-management of international normalized ratio (INR) with home point-of-care INR monitoring for vitamin K antagonist therapy and against using periprocedural low-molecular-weight heparin (LMWH) bridging therapy. Conditional recommendations included basing treatment dosing of LMWH on actual body weight, not using anti-factor Xa monitoring to guide LMWH dosing, using specialized anticoagulation management services, and resuming anticoagulation after episodes of life-threatening bleeding.

Indexed as

Administration, OralAnticoagulantsATP Binding Cassette Transporter, Subfamily BCytochrome P-450 Enzyme SystemEvidence-Based MedicineHeparinHeparin, Low-Molecular-WeightHumansInternational Normalized RatioMedication AdherencePoint-of-Care SystemsVenous ThromboembolismVitamin KAnticoagulantsATP Binding Cassette Transporter, Subfamily BCytochrome P-450 Enzyme SystemHeparinHeparin, Low-Molecular-WeightVitamin K

Identifiers

PMID30482765
PMCPMC6258922
OpenAlexW2902233584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.