Evidence map›Paper›PMID 30482711›Full record

ArticleUltrasound in medicine & biology2019

Multiple-Exposure Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a Potential Degenerative Disc Disease Treatment.

Khoi Nguyen, Hsuan-Yeh Pan, Kevin Haworth, Eric Mahoney, Karla P Mercado-Shekhar, Chia-Ying Lin, Zhe Zhang, Yoonjee C Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Stimuli-Responsive Drug Release from Smart Polymers.Journal of functional biomaterials · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Khoi NguyenDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio, USA.
Hsuan-Yeh PanDepartment of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Kevin HaworthDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio, USA; Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Eric MahoneyDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio, USA.
Karla P Mercado-ShekharDepartment of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Chia-Ying LinDepartment of Orthopaedic Surgery, University of Cincinnati, Cincinnati, Ohio, USA.
Zhe ZhangDepartment of Chemical & Environmental Engineering, University of Cincinnati, Cincinnati, Ohio, USA.
Yoonjee C ParkDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio, USA; Department of Chemical & Environmental Engineering, University of Cincinnati, Cincinnati, Ohio, USA. Electronic address: parkye@ucmail.uc.edu.
University of Cincinnati · US

Funding

KL2 Training ProgramKL2TR001426 · NCATS · UNIVERSITY OF CINCINNATI · PI ZELLER, MARGARET H · 2015 to 2024
$6.8M
Simvastatin to Retard Degenerative Disc DiseaseR01AR056649 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIN, CHIA-YING JAMES · 2010 to 2013
$1.3M
NCATS NIH HHS KL2 TR001426NIAMS NIH HHS R01 AR056649
6 · The paper itself

Abstract

The combination of simvastatin and CF680 dye encapsulated by stable nanodroplets has been developed as a drug delivery carrier. Simvastatin has previously been found to be a potential degenerative disc disease treatment. Multiple exposures of the nanodroplets to high-intensity focused ultrasound induced release of simvastatin. Each ultrasound exposure yielded a consistent concentration of the drug and dye released. B-mode ultrasound image analysis data and cavitation data clearly indicated the release mechanism is phase transition of the liquid nanodroplets into gas bubbles. The nanodroplets were stably stored in ex vivo rabbit spinal discs for at least 14 days, and the contents responded to ultrasound exposure on demand. Lastly, nucleus pulposus cells harvested from rabbit spine discs and exposed to media with nanodroplets exhibited a decrease in cell viability (85%) relative to the cells only (96.7%) at 24 h, but no difference at 48 h. Thus, the system may be a potential degenerative disc disease treatment.

Indexed as

Drug LiberationAnimalsDisease Models, AnimalDrug Delivery SystemsExtracorporeal Shockwave TherapyHydroxymethylglutaryl-CoA Reductase InhibitorsIntervertebral DiscIntervertebral Disc DegenerationNanoparticlesRabbitsSimvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsSimvastatinDegenerative disc diseaseHigh-intensity focused ultrasoundMultiple releasesOn-demand drug release

Identifiers

PMID30482711
PMCPMC6290355
OpenAlexW2898490985

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.