Evidence map›Paper›PMID 30482659›Full record

ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2019

Disclosure and Clinical Outcomes Among Young Adolescents Living With HIV in Kenya.

Bernadette Ngeno, Anthony Waruru, Irene Inwani, Lucy Nganga, Evelyn Ngugi Wangari, Abraham Katana, Anthony Gichangi, Ann Mwangi, Irene Mukui, George W Rutherford

Abstract readMulticenter Study
In one paragraph

Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  6. Lived Experiences of Adolescents with HIV in Rwanda: A Phenomenology Study.Rwanda journal of medicine and health sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bernadette NgenoDivision of Global HIV & TB, US Centers for Disease Control and Prevention, Atlanta, Georgia. Electronic address: uyt0@cdc.gov.
Anthony WaruruDivision of Global HIV & TB, US Centers for Disease Control and Prevention, CDC-Kenya, Nairobi, Kenya.
Irene InwaniKenyatta National Hospital, Nairobi, Kenya.
Lucy NgangaDivision of Global HIV & TB, US Centers for Disease Control and Prevention, CDC-Kenya, Nairobi, Kenya.
Evelyn Ngugi WangariDivision of Global HIV & TB, US Centers for Disease Control and Prevention, CDC-Kenya, Nairobi, Kenya.
Abraham KatanaDivision of Global HIV & TB, US Centers for Disease Control and Prevention, CDC-Kenya, Nairobi, Kenya.
Anthony GichangiDivision of Global HIV & TB, US Centers for Disease Control and Prevention, CDC-Kenya, Nairobi, Kenya.
Ann MwangiNational AIDS and STI Control Programme, Ministry of Health, Annex Kenyatta National Hospital Grounds, Nairobi, Kenya.
Irene MukuiNational AIDS and STI Control Programme, Ministry of Health, Annex Kenyatta National Hospital Grounds, Nairobi, Kenya.
George W RutherfordInstitute for Global Health Sciences, University of California, San Francisco, San Francisco California.

Funding

PS09-990: CDC KENYA - MONITORING AND EVALUATION (M&E)U2GPS001814 · PS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUTHERFORD, GEORGE WILLIAMS · 2009 to 2014
$7.7M
CGH CDC HHS U19 GH000069NCHHSTP CDC HHS U2G PS001814PEPFAR
6 · The paper itself

Abstract

purposeInforming adolescents of their own HIV infection is critical as the number of adolescents living with HIV increases. We assessed the association between HIV disclosure and retention in care and mortality among adolescents aged 10-14 years in Kenya's national program.

methodsWe abstracted routinely collected patient-level data for adolescents enrolled into HIV care in 50 health facilities from November 1, 2004, through March 31, 2010. We defined disclosure as any documentation that the adolescent had been fully or partially made aware of his or her HIV status. We compared weighted proportions for categorical variables using χ2 and weighted logistic regression to identify predictors of HIV disclosure; we estimated the probability of LTFU using Kaplan-Meier methods and dying using Cox regression-based test for equality of survival curves.

resultsOf the 710 adolescents aged 10-14 years analyzed; 51.3% had severe immunosuppression, 60.3% were in WHO stage 3 or 4, and 36.6% were aware of their HIV status. Adolescents with HIV-infected parents, histories of opportunistic infections (OIs), and enrolled in support groups were more likely to be disclosed to. At 36 months, disclosure was associated with lower mortality [1.5% (95% CI .6%-4.1%) versus 5.4% (95% CI 3.6.6%-8.0%, p < .001)] and lower LTFU [6.2% (95% CI 3.0%-12.6%) versus 33.9% (95% CI 27.3%-41.1%) p < .001].

conclusionsOnly one third of HIV-infected Kenyan adolescents in treatment programs had been told they were infected, and knowing their HIV status was associated with reduced LTFU and mortality. The disclosure process should be systematically encouraged and organized for HIV-infected adolescents.

Indexed as

AdolescentCase-Control StudiesChildChild, PreschoolDisclosureFemaleHIV InfectionsHumansKenyaMaleOutcome and Process Assessment, Health CareProportional Hazards ModelsRandom AllocationRetrospective StudiesAdolescentsDisclosureHIVKenya

Identifiers

PMID30482659
PMCPMC6375672

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.