SynthesisThe Journal of thoracic and cardiovascular surgery2019
A systematic review and meta-analysis of stereotactic body radiation therapy versus surgery for patients with non-small cell lung cancer.
Synthesis in The Journal of thoracic and cardiovascular surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Stereotactic body radiotherapy versus surgery for early-stage non-small cell lung cancer: an updated meta-analysis involving 29,511 patients included in comparative studies.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022Pooled it
- Survival outcomes for surgical resection versus CT-guided percutaneous ablation for stage I non-small cell lung cancer (NSCLC): a systematic review and meta-analysis.European radiology · 2021Pooled it
- Racial and ethnic disparities in receipt of guideline-concordant treatment for early-stage non-small cell lung cancer.Cancer causes & control : CCC · 2026Article
- Comparison of prognosis between patients undergoing surgical resection and stereotactic ablative radiotherapy for early-stage lung cancer.BMC cancer · 2026Article
- Wedge Resection vs Stereotactic Body Radiation Therapy for Stage 1 Non-Small Cell Lung Cancer in Octogenarians.Annals of thoracic surgery short reports · 2026Article
- Deep Learning for CT Synthesis in Radiotherapy.Bioengineering (Basel, Switzerland) · 2025Review
- Comparison of surgery and stereotactic body radiation therapy for clinical stage I NSCLC: a propensity score-matched analysis from a single institution.Journal of thoracic disease · 2025Article
- Durvalumab consolidation after chemoradiotherapy for locoregional recurrent non-small cell lung cancer.Molecular and clinical oncology · 2025Article
- Article
- Dosimetric comparison of two linear accelerators for lung cancer SBRT using IMRT dose delivery technique: VenusX vs. Edge.European journal of medical research · 2025Article
- Review
- Dynamic chest radiography in post-lobectomy recovery: a novel approach to evaluating pulmonary function and thoracic structures in patients with primary lung cancer.Quantitative imaging in medicine and surgery · 2025Article
- Pulmonary artery enlargement as a predictor of long-term prognosis in patients with resected early-stage non-small cell lung cancer.JTCVS open · 2025Article
- Observational
- Similar overall survivals of wedge resection and segmentectomy in stage IA1 non-small cell lung cancer: a population-based study using propensity score matching and coarsened exact matching.Journal of thoracic disease · 2024Article
- EXACT-Net: Framework for EHR-Guided Lung Tumor Auto-Segmentation for Non-Small Cell Lung Cancer Radiotherapy.Cancers · 2024Article
- Review
- Article
- Next-Generation Lung Cancer Surgery: A Brief Trip into the Future of the Research.Journal of clinical medicine · 2023Article
- Comparison of stereotactic body radiation therapy versus surgery for multiple primary lung cancers after prior radical resection: A multicenter retrospective study.Clinical and translational radiation oncology · 2023Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveStereotactic body radiation therapy is the preferred treatment modality for patients with inoperable early-stage non-small cell lung cancer. However, comparative outcomes between stereotactic body radiation therapy and surgery for high-risk patients remain controversial. The primary aim of the present meta-analysis was to assess overall survival in matched and unmatched patient cohorts undergoing stereotactic body radiation therapy or surgery. Secondary end points included cancer-specific survival, disease-free survival, disease recurrence, and perioperative outcomes.
methodsA systematic review of relevant studies was performed through online databases using predefined criteria. The most updated studies were selected for meta-analysis according to unmatched and matched patient cohorts.
resultsThirty-two studies were identified in the systematic review, and 23 were selected for quantitative analysis. Surgery was associated with superior overall survival in both unmatched (odds ratio, 2.49; 95% confidence interval, 2.10-2.94; P < .00001) and matched (odds ratio, 1.71; 95% confidence interval, 1.52-1.93; P < .00001) cohorts. Subgroup analysis demonstrated superior overall survival for lobectomy and sublobar resection compared with stereotactic body radiation therapy. In unmatched and matched cohorts, cancer-specific survival, disease-free survival, and freedom from locoregional recurrence were superior after surgery. However, stereotactic body radiation therapy was associated with fewer perioperative deaths.
conclusionsThe current evidence suggests surgery is superior to stereotactic body radiation therapy in terms of mid- and long-term clinical outcomes; stereotactic body radiation therapy is associated with lower perioperative mortality. However, the improved outcomes after surgery may be due at least in part to an imbalance of baseline characteristics. Future studies should aim to provide histopathologic confirmation of malignancy and compare stereotactic body radiation therapy with minimally invasive anatomical resections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.