Evidence map›Paper›PMID 30482213›Full record

ArticleRetrovirology2018

MBL2 gene polymorphisms in HHV-8 infection in people living with HIV/AIDS.

Viviane Martha Santos de Morais, Elker Lene Santos de Lima, Georgea Gertrudes de Oliveira Mendes Cahú, Thaisa Regina Rocha Lopes, Juliana Prado Gonçales, Maria Tereza Cartaxo Muniz, Maria Rosângela Cunha Duarte Coêlho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Retrovirology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Viviane Martha Santos de MoraisVirology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, PE, 50670-901, Brazil.
Elker Lene Santos de LimaLaboratory of Molecular Biology, Center of Pediatric Oncohematology, Oswaldo Cruz University Hospital, University of Pernambuco, Recife, PE, Brazil.
Georgea Gertrudes de Oliveira Mendes CahúVirology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, PE, 50670-901, Brazil.
Thaisa Regina Rocha LopesVirology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, PE, 50670-901, Brazil.
Juliana Prado GonçalesVirology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, PE, 50670-901, Brazil.
Maria Tereza Cartaxo MunizLaboratory of Molecular Biology, Center of Pediatric Oncohematology, Oswaldo Cruz University Hospital, University of Pernambuco, Recife, PE, Brazil.
Maria Rosângela Cunha Duarte CoêlhoVirology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, PE, 50670-901, Brazil. rcoelholika@gmail.com.
Universidade Federal de Pernambuco · BRUniversidade de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHost genetic factors such as MBL2 gene polymorphisms cause defects in the polymerization of MBL protein and result in a functional deficiency and/or in low serum levels that can influence susceptibility to various viral infections. The aim of this study was to estimate the frequency of alleles, genotypes and haplotypes related to -550, -221 and exon 1 polymorphisms of the MBL2 gene and investigate their association with HHV-8 in people living with HIV/AIDS (PLWHA), as well as the impacts on CD4 cell count and HIV viral load in HIV/HHV-8 coinfected and HIV monoinfected patients.

resultsA cross sectional study in PLWHA, with and without HHV-8 infection, exploring associations between different factors, was performed in the outpatient infectious and parasitic diseases clinic at a referral hospital. Genomic DNA extractions from leukocytes were performed using a commercial Wizard

conclusionsHost genetic factors, such as -550, -221 and exon 1 polymorphisms, can be related to the may modify coinfections and/or to the development clinical manifestations caused by HHV-8, especially in HIV/HHV-8 coinfected patients who present the intermediate expression haplotypes of MBL.

Indexed as

Polymorphism, Single NucleotideAdultAllelesCD4 Lymphocyte CountCross-Sectional StudiesFemaleGenetic Predisposition to DiseaseGenotypeHaplotypesHerpesviridae InfectionsHerpesvirus 8, HumanHIV InfectionsHumansMaleMannose-Binding LectinMiddle AgedMannose-Binding LectinMBL2 protein, humanHIV/HHV-8 coinfectionHuman herpesvirus 8Mannose binding lectinMBL2 gene

Identifiers

PMID30482213
PMCPMC6260567
OpenAlexW2902481565

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.