Evidence map›Paper›PMID 30482205›Full record

ArticleEnvironmental health : a global access science source2018

Breast cancer risk and serum levels of per- and poly-fluoroalkyl substances: a case-control study nested in the California Teachers Study.

Susan Hurley, Debbie Goldberg, Miaomiao Wang, June-Soo Park, Myrto Petreas, Leslie Bernstein, Hoda Anton-Culver, David O Nelson, Peggy Reynolds

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health : a global access science source, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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  14. Exposure to environmental chemicals and cancer risk: epidemiological evidence from Japanese studies.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Susan HurleyCancer Prevention Institute of California, Berkeley, CA, USA. susan.hurley@ucsf.edu.ORCID 0000-0002-5582-1741
Debbie GoldbergCancer Prevention Institute of California, Berkeley, CA, USA.
Miaomiao WangEnvironmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, CA, USA.
June-Soo ParkEnvironmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, CA, USA.
Myrto PetreasEnvironmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, CA, USA.
Leslie BernsteinDepartment of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Hoda Anton-CulverDepartment of Epidemiology, School of Medicine, University of California Irvine, Irvine, CA, USA.
David O NelsonCancer Prevention Institute of California, Berkeley, CA, USA.
Peggy ReynoldsCancer Prevention Institute of California, Berkeley, CA, USA.
Cancer Prevention Institute of California · USCalifornia Department of Toxic Substances Control · USCity of Hope · USUniversity of California, Irvine · US

Funding

CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA77398
6 · The paper itself

Abstract

backgroundPer- and poly- fluoroalkyl substances (PFASs) are a large family of synthetic chemicals, some of which are mammary toxicants and endocrine disruptors. Their potential as breast carcinogens is unclear. Our objective was to evaluate the risk of breast cancer associated with serum PFAS concentrations in a nested case-control study within the California Teachers Study.

methodsParticipants were 902 women with invasive breast cancer (cases) and 858 with no such diagnosis (controls) who provided 10 mL of blood and were interviewed during 2011-2015, an average of 35 months after case diagnosis. PFASs were measured using automated online SPE-HPLC-MS/MS methods. Statistical analyses were restricted to six PFASs with detection frequencies ≥ 95%: PFOA (Perfluorooctanoic acid), PFNA (Perfluorononanoic acid), PFUnDA (Perfluoroundecanoic acid), PFHxS (Perfluorohexane sulfonic acid), PFOS (Perfluorooctane sulfonic acid), and MeFOSAA (2-(N-Methyl-perfluorooctane sulfonamido) acetic acid. Unconditional logistic regression was used to calculate adjusted odds ratios (ORs), estimating the breast cancer risk associated with each PFAS.

resultsFor all cases of invasive breast cancer, none of the adjusted ORs were statistically significant but marginally significant ORs < 1.0 were observed for PFUnDA and PFHxS (p-trend = 0.08). Adjusted ORs < 1.0 for PFUnDA and PFHxS were statistically significant (p ≤ 0.05) among the 107 cases with hormone-negative tumors but not the 743 with hormone-positive tumors.

conclusionOverall, these findings do not provide evidence that serum PFAS levels measured after diagnosis are related to breast cancer risk. The few inverse associations found may be due to chance or may be artifacts of study design. Future studies should incorporate information about genetic susceptibility, endogenous estrogen levels, and measurements of PFASs prior to diagnosis and treatment.

Indexed as

AdultAgedAged, 80 and overAlkanesulfonic AcidsBreast NeoplasmsCaliforniaCase-Control StudiesEnvironmental MonitoringEnvironmental PollutantsFatty AcidsFemaleFluorocarbonsHumansMiddle AgedOdds RatioRiskAlkanesulfonic AcidsEnvironmental PollutantsFatty AcidsFluorocarbonsBreast cancer riskCase controlPerfluoroalkyl substancesPFASPolyfluoroalkyl substances

Identifiers

PMID30482205
PMCPMC6260688
OpenAlexW2902361674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.