Evidence map›Paper›PMID 30482194›Full record

Trial reportBMC complementary and alternative medicine2018

Emotional release and physical symptom improvement: a qualitative analysis of self-reported outcomes and mechanisms in patients treated with neural therapy.

Heidemarie Haller, Felix J Saha, Barbara Ebner, Anna Kowoll, Dennis Anheyer, Gustav Dobos, Bettina Berger, Kyung-Eun Choi

Registry-linked trialOpen access · goldAbstract readClinical Trial
In one paragraph

Trial report in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06912438 (Emotional Release After Trigger Point Needling to Treat Myofascial Pain of the Head and Neck - Prospective Study), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06912438 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Emotional Release After Trigger Point Needling to Treat Myofascial Pain of the Head and Neck - Prospective Study

Typeobservational_patient_registrySponsorTel-Aviv Sourasky Medical CenterRan2025 to 2027Enrolled100ConditionsTemporomandibular Disorders (TMD), Temporomandibular Dysfunction (TMD), Temporomandibular Joint and Muscle DisorderArmsFill out questionnaire
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Heidemarie HallerDepartment of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany. h.haller@kem-med.com.ORCID http://orcid.org/0000-0001-7973-4071
Felix J SahaDepartment of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
Barbara EbnerDepartment of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
Anna KowollDepartment of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
Dennis AnheyerDepartment of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
Gustav DobosDepartment of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
Bettina BergerInstitute for Integrative Medicine, Department of Health, Witten/Herdecke University, Herdecke, Germany.
Kyung-Eun ChoiDepartment of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
Kliniken Essen-Mitte · DEUniversity of Cologne · DEWitten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeural Therapy (NT) is a common complementary treatment approach using injections with short-acting local anesthetics to treat pain and chronic diseases. However, little is known about the underlying mechanisms and the domains of treatment response. This study therefore analyzed patient experiences following NT injections with procaine.

methodsMaximum variation sampling was used to collect data from semi-structured interviews conducted with 22 hospital inpatients aged 59.6 ± 14.9 years (81.8% female). Each had multiple (9.4 ± 6.9) diagnoses. They were undergoing two weeks of integrative treatment, which included individualized NT. The interview data were analyzed in MAXQDA using qualitative content analysis.

resultsWith injection, patients first described local anesthetic effects including temporary blocking of pain and increased local warmth. Second, patients reported on vegetative reactions frequently leading to turmoil within the body like initial aggravation of existing symptoms or the appearance of new, concealed or phantom symptoms. This often required the need for rest to deal with the treatment stimulus. As a third step, many patients could gain physical and emotional release and relief in symptoms, mood and functioning. Emotional release was often accompanied by weeping and initially overwhelmed affected patients with dissociated memories. However, in cases where patients were able to experience those memories with a new distance, a fourth step of integration was achievable. It included reframing processes as well as a gain in pain perception and body-awareness. As a possible fifth step, patients experienced improved mood, increased pain acceptance and empowerment. Adverse events of NT included pain from the injections, vegetative complaints and emotional turmoil that lasted for minutes or hours, with a maximum of two days.

conclusionsPatients treated with procaine injections reported different psychophysiological outcomes contributing to the understanding of the mechanisms underlying NT. Further efficacy studies should separate specific NT from non-specific/placebo effects.

trial registrationDRKS00004567 .

Indexed as

AdultAffectAgedAnesthesia, LocalAnesthetics, LocalChronic PainEmotionsEvaluation Studies as TopicFemaleHumansMaleMiddle AgedProcaineSelf ReportAnesthetics, LocalProcaineBody ImageChronic DiseaseEmotionsNeural therapyProcaineQualitative Research

Identifiers

PMID30482194
PMCPMC6258402
OpenAlexW2903456775

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.