Evidence map›Paper›PMID 30482165›Full record

ArticleBMC cancer2018

Prevalence of breast and ovarian cancer subtypes in Hispanic populations from Puerto Rico.

Ariel Rodriguez-Velazquez, Rosa Velez, Jean Carlo Lafontaine, Claudia B Colon-Echevarria, Rocio D Lamboy-Caraballo, Ingrid Ramirez, Adalberto Mendoza, Patricia Casbas-Hernandez, Guillermo N Armaiz-Pena

Open access · goldAbstract read
In one paragraph

Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ariel Rodriguez-VelazquezDepartment of Basic Sciences, Division of Biochemistry, School of Medicine, Ponce Health Sciences University, Ponce, PR, USA.
Rosa VelezSouthern Pathology Services Inc, Ponce, PR, USA.
Jean Carlo LafontaineDepartment of Basic Sciences, Division of Pharmacology, School of Medicine, Ponce Health Sciences University, Ponce, PR, USA.
Claudia B Colon-EchevarriaDepartment of Basic Sciences, Division of Pharmacology, School of Medicine, Ponce Health Sciences University, Ponce, PR, USA.
Rocio D Lamboy-CaraballoDepartment of Basic Sciences, Division of Pharmacology, School of Medicine, Ponce Health Sciences University, Ponce, PR, USA.
Ingrid RamirezDepartment of Obstetrics and Gynecology, School of Medicine, Ponce Health Sciences University, Ponce, PR, USA.
Adalberto MendozaSouthern Pathology Services Inc, Ponce, PR, USA.
Patricia Casbas-HernandezDepartment of Basic Sciences, Division of Biochemistry, School of Medicine, Ponce Health Sciences University, Ponce, PR, USA.
Guillermo N Armaiz-PenaDepartment of Basic Sciences, Division of Pharmacology, School of Medicine, Ponce Health Sciences University, Ponce, PR, USA. garmaiz@psm.edu.ORCID http://orcid.org/0000-0002-9081-5339
Ponce Health Sciences University · PR

Funding

SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Jose R. Rodriguez-Medina · 2012 to 2026
$52.9M
TECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54MD007587 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LUCIANO, CARLOS A., WOJNA, VALERIE · 2012 to 2018
$23.2M
Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163068 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Shannon Marie Christy · 2012 to 2026
$23.1M
Using MC1R genotype to impact skin cancer risk behaviors in Hispanics/LatinosU54CA163071 · NCI · PONCE SCHOOL OF MEDICINE · PI Harold I Saavedra · 2012 to 2026
$23.0M
VIRAL SEQUENCES IN PEDIATRIC HIV INFECTION IN PRG12MD007579 · NIMHD · PONCE SCHOOL OF MEDICINE · PI NOEL, RICHARD J. · 2012 to 2018
$15.9M
RISE Option III: Ponce School of Medicine MBRS-RISE ProgramR25GM082406 · NIGMS · PONCE SCHOOL OF MEDICINE · PI APPLEYARD, CAROLINE B · 2008 to 2021
$9.5M
FUNCTIONAL ANALYSIS OF BRCA1 MUTANTSR01CA092309 · NCI · STRANG CANCER PREVENTION CENTER · PI MONTEIRO, ALVARO N · 2002 to 2006
$1.3M
Role of IkBKe in Stress-Induced Ovarian Cancer ProgressionF31CA232622 · NCI · PONCE SCHOOL OF MEDICINE · PI COLON-ECHEVARRIA, CLAUDIA B. · 2018 to 2020
$74k
NCI NIH HHS F31 CA232622NCI NIH HHS R01 CA092309NCI NIH HHS U54 CA163068NCI NIH HHS U54CA163068NCI NIH HHS U54 CA163071NCI NIH HHS U54CA163071NIGMS NIH HHS P20 GM103475NIGMS NIH HHS P20GM103475NIGMS NIH HHS R25 GM082406NIGMS NIH HHS R25GM082406NIMHD NIH HHS G12 MD007579NIMHD NIH HHS G12MD007579NIMHD NIH HHS U54 MD007587NIMHD NIH HHS U54MD007587
6 · The paper itself

Abstract

backgroundPrevious epidemiological studies aimed at describing characteristics of breast (BC) and ovarian cancer (OC) patients tend to examine Hispanic populations using a mix of individuals that come from ethnically different Hispanic backgrounds. Since most USA cancer statistics do not include cancer data from Puerto Rico (PR), there is a lack of historical and descriptive data analysis for Hispanic women in the island that suffer from these diseases. Therefore, the aim of our study is to provide a comprehensive clinicopathological characterization of BC and OC cases in PR.

methodsOur study consisted of a longitudinal retrospective review of archived pathology reports at Southern Pathology Services (SPS), which mostly serves southwestern PR, from years 2000-2015. After filtering SPS records with pre-established criteria, tumor samples from 3451 BC and 170 OC cases were used for descriptive statistics and analysis using R program.

resultsIn our cohort, the mean age of diagnosis for BC was 60.5 years and 60.3 years for OC. Available data for subtype characterization from BC cases, exhibited an expected subtype distribution that remained stable over time (Luminal A = 68.8%, Luminal B = 9.7%, HER-2 = 6.1% and Triple negative = 15.4%). Additionally, tumor grades distribution varied within different BC subtypes in which the majority of Luminal A tumors were G2 and most Triple negative tumors were G3. For OC cases, available subtype and tumor grade information identified serous histology in 64.71% of all cases and G3 as being the most prevalent tumor grade. Pathology reports revealed that 39.42% of all OC cases were described as late stage, while 50.5% as early stage (by pathological staging).

conclusionOur data suggests that OC and BC subtypes distribution in Hispanic populations from PR are in-line with national averages. In a significant number of BC cases, subtype could not be determined due to study limitations, health insurance coverage, or other reasons described here and may constitute a health disparity. Altogether, and despite these gaps, this study represents one of the most complete reviews of BC and OC in PR and provides an opportunity to further study this population separate from other US Hispanic populations.

Indexed as

Hispanic or LatinoAdultAgedAnalysis of VarianceBiomarkers, TumorBreast NeoplasmsFemaleHealthcare DisparitiesHumansImmunohistochemistryMiddle AgedNeoplasm GradingNeoplasm StagingOvarian NeoplasmsPopulation SurveillancePrevalenceBiomarkers, TumorBreast cancerHealth disparitiesHispanicsLatinosOvarian cancerPuerto Rico

Identifiers

PMID30482165
PMCPMC6260719
OpenAlexW2903241132

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.