Evidence map›Paper›PMID 30482023›Full record

ArticleBiointerphases2018

Surface-grafted antimicrobial drugs: Possible misinterpretation of mechanism of action.

Javad Naderi, Carla Giles, Solmaz Saboohi, Hans J Griesser, Bryan R Coad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biointerphases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 10 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Javad NaderiFuture Industries Institute, University of South Australia, Adelaide 5000, Australia.
Carla GilesDepartment of Primary Industries Parks Water and Environment Tasmania, Centre for Aquatic Animal Health and Vaccines, 165 Westbury Road, Prospect, Tasmania 7250, Australia.
Solmaz SaboohiFuture Industries Institute, University of South Australia, Adelaide 5000, Australia.
Hans J GriesserFuture Industries Institute, University of South Australia, Adelaide 5000, Australia.
Bryan R CoadFuture Industries Institute, University of South Australia, Adelaide 5000, Australia.
University of South Australia · AUUniversity of Adelaide · AU

Funding

Surface Analysis Facility for Biomedical ProblemsP41EB002027 · NIBIB · UNIVERSITY OF WASHINGTON · PI CASTNER, DAVID G · 2003 to 2019
$17.6M
NIBIB NIH HHS P41 EB002027
6 · The paper itself

Abstract

Antimicrobial surface coatings that act through a contact-killing mechanism (not diffusive release) could offer many advantages to the design of medical device coatings that prevent microbial colonization and infections. However, as the authors show here, to prevent arriving at an incorrect conclusion about their mechanism of action, it is essential to employ thorough washing protocols validated by surface analytical data. Antimicrobial surface coatings were fabricated by covalently attaching polyene antifungal drugs to surface coatings. Thorough washing (often considered to be sufficient to remove noncovalently attached molecules) was used after immobilization and produced samples that showed a strong antifungal effect, with a log 6 reduction in

Indexed as

Surface PropertiesAntifungal AgentsCandida albicansCoated Materials, BiocompatibleColony Count, MicrobialPhotoelectron SpectroscopyPolyenesSpectrometry, Mass, Secondary IonAntifungal AgentsCoated Materials, BiocompatiblePolyenes

Identifiers

PMID30482023
PMCPMC6905654
OpenAlexW2902890174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.