Evidence map›Paper›PMID 30481769›Full record

ArticleNeonatology2019

Platelet-Neutrophil Interactions Are Lower in Cord Blood of Premature Newborns.

Ijeoma Esiaba, Danilyn M Angeles, Terry-Ann M Milford, Lorena M Salto, Kimberly J Payne, Melissa Y Kidder, Danilo S Boskovic

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neonatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Platelets in the neonate: Not just a small adult.Research and practice in thrombosis and haemostasis · 2022
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ijeoma EsiabaDepartment of Earth and Biological Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA.
Danilyn M AngelesDivision of Physiology, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA.
Terry-Ann M MilfordDivision of Anatomy, Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, Loma Linda, California, USA.
Lorena M SaltoCenter for Health Disparities and Molecular Medicine, School of Medicine, Loma Linda University, Loma Linda, California, USA.
Kimberly J PayneDivision of Anatomy, Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, Loma Linda, California, USA.
Melissa Y KidderDepartment of Obstetrics and Gynecology, School of Medicine, Loma Linda University, Loma Linda, California, USA.
Danilo S BoskovicDepartment of Earth and Biological Sciences, School of Medicine, Loma Linda University, Loma Linda, California, USA, dboskovic@llu.edu.
Loma Linda University · US

Funding

NIH-LLU Initiative for Maximizing Student DiversityR25GM060507 · NIGMS · LOMA LINDA UNIVERSITY · PI DE LEON, MARINO · 2001 to 2022
$11.3M
Research Training/Education CoreP20MD006988 · NIMHD · LOMA LINDA UNIVERSITY · PI CASIANO, CARLOS A. · 2012 to 2016
$6.2M
Pain and Hypoxia in Premature NeonatesR01NR011209 · NINR · LOMA LINDA UNIVERSITY · PI ANGELES, DANILYN MAG-AKAT · 2009 to 2017
$2.9M
NIGMS NIH HHS R25 GM060507NIMHD NIH HHS P20 MD006988NINR NIH HHS R01 NR011209
6 · The paper itself

Abstract

objectiveTo quantify platelet-neutrophil interaction by flow cytometry, in newborn cord blood, as a function of gestational age. RATIONALE: Little is known about platelet function markers in the newborn, and developmental variations in these markers are not well described.

methodsCord blood samples were obtained from 64 newborns between 23 and 40 weeks' gestation. The neonates were grouped into three categories: preterm (< 34 weeks' gestation, n = 21), late preterm (34 to < 37 weeks' gestation, n = 22), and term (≥37 weeks' gestation, n = 21). We monitored the expression of P-selectin and the formation of platelet-neutrophil aggregates (PNAs) by flow cytometry while using adenosine 5'-diphosphate (ADP) or thrombin receptor-activating peptide (TRAP) as agonists.

resultsPNAs were significantly lower in preterm compared to term neonates after TRAP or ADP stimulations (11.5 ± 5.2% vs. 19.9 ± 9.1%, p < 0.001, or 24.0 ± 10.1% vs. 39.1 ± 18.2%, p = 0.008, respectively). The expression of P-selectin also tended to be lower in preterm neonates, with significant positive correlations between P-selectin expression and PNA formation.

conclusionsThe potential formation of PNAs correlates with gestational age. This suggests that the development of functional competencies of platelets and neutrophils continues throughout gestation, progressively enabling interactions between them.

Indexed as

Adenosine DiphosphateBlood PlateletsFemaleFetal BloodFlow CytometryGestational AgeHumansInfant, NewbornInfant, PrematureMaleNeutrophilsPeptide FragmentsP-SelectinAdenosine DiphosphatePeptide FragmentsP-Selectinthrombin receptor-activating peptide (P508-530)NeutrophilNeutrophil functionPlateletPlatelet activationPlatelet functionPlatelet-neutrophil interactionPrematurity

Identifiers

PMID30481769
PMCPMC6559727
OpenAlexW2902469199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.