Evidence map›Paper›PMID 30481595›Full record

ArticleBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2019

Fluoroquinolone Prophylaxis Is Highly Effective for the Prevention of Central Line-Associated Bloodstream Infections in Autologous Stem Cell Transplant Patients.

Matthew Ziegler, Daniel Landsburg, David Pegues, Warren Bilker, Cheryl Gilmar, Colleen Kucharczuk, Theresa Gorman, Kristen Bink, Amy Moore, Rebecca Fitzpatrick and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Matthew ZieglerDivision of Infectious Diseases, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: matthew.ziegler@uphs.upenn.edu.
Daniel LandsburgDivision of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
David PeguesDivision of Infectious Diseases, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Healthcare Epidemiology, Infection Prevention and Control, University of Pennsylvania, Philadelphia, Pennsylvania.
Warren BilkerDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Cheryl GilmarDepartment of Healthcare Epidemiology, Infection Prevention and Control, University of Pennsylvania, Philadelphia, Pennsylvania.
Colleen KucharczukDivision of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Theresa GormanDivision of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Kristen BinkDivision of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Amy MooreDepartment of Healthcare Epidemiology, Infection Prevention and Control, University of Pennsylvania, Philadelphia, Pennsylvania.
Rebecca FitzpatrickDepartment of Healthcare Epidemiology, Infection Prevention and Control, University of Pennsylvania, Philadelphia, Pennsylvania.
Edward A StadtmauerDivision of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Patricia ManganDivision of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Kelly KrausDivision of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania.
Jennifer H HanDivision of Infectious Diseases, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Healthcare Epidemiology, Infection Prevention and Control, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
University of Pennsylvania · US

Funding

Infectious Diseases Epidemiology Training GrantT32AI055435 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI LAUTENBACH, EBBING · 2003 to 2023
$6.9M
Carbapenem-Resistant Klebsiella Pneumoniae in Long-Term Acute Care HospitalsK01AI103028 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAN, JENNIFER · 2013 to 2017
$669k
NCEZID CDC HHS U54 CK000485NIAID NIH HHS K01 AI103028NIAID NIH HHS T32 AI055435
6 · The paper itself

Abstract

Patients undergoing stem cell transplant (SCT) for the treatment of hematologic malignancy are at increased risk for central line-associated bloodstream infections (CLABSIs). The use of prophylactic antibiotics to prevent CLABSIs in the setting of autologous SCT is of unclear benefit. We aimed to evaluate the impact of levofloxacin prophylaxis on reducing CLABSIs in this high-risk population. Patients undergoing autologous SCT at a tertiary care hospital received levofloxacin prophylaxis from January 13, 2016 to January 12, 2017. Levofloxacin was administered from autologous SCT (day 0) until day 13, absolute neutrophil count > 500/mm

Indexed as

AdultAnti-Bacterial AgentsAntibiotic ProphylaxisBacteremiaClostridium InfectionsFebrile NeutropeniaFemaleHematologic NeoplasmsHematopoietic Stem Cell TransplantationHumansInfection ControlInfectionsLevofloxacinMaleMiddle AgedSepsisAnti-Bacterial AgentsLevofloxacinBacteremiaCentral venous cathetersHematopoietic stem cellLevofloxacinTransplantation

Identifiers

PMID30481595
PMCPMC6511289
OpenAlexW2901354400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.