Evidence map›Paper›PMID 30481375›Full record

ReviewJournal of surgical oncology2019

Updates in adjuvant systemic therapy for melanoma.

Minyoung Kwak, Norma E Farrow, April K S Salama, Paul J Mosca, Brent A Hanks, Craig L Slingluff, Georgia M Beasley

Abstract readReview
In one paragraph

Review in Journal of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Minyoung KwakDepartment of Surgery, University of Virginia, Charlottesville, Virginia.
Norma E FarrowDepartment of Surgery, Duke University, Durham, North Carolina.
April K S SalamaDepartment of Medicine, Duke University, Durham, North Carolina.
Paul J MoscaDepartment of Surgery, Duke University, Durham, North Carolina.
Brent A HanksDepartment of Medicine, Duke University, Durham, North Carolina.
Craig L SlingluffDepartment of Surgery, University of Virginia, Charlottesville, Virginia.
Georgia M BeasleyDepartment of Surgery, Duke University, Durham, North Carolina.ORCID http://orcid.org/0000-0001-6387-9030

Funding

Cancer Research Training Program: From Molecular Mechanisms to Therapeutic StrategiesT32CA009109 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Andrew Carl Dudley, Melanie R Rutkowski · 1985 to 2026
$13.9M
Melanoma-mediated Dendritic Cell Tolerization and Immune EvasionK08CA191063 · NCI · DUKE UNIVERSITY · PI HANKS, BRENT ALLEN · 2015 to 2019
$826k
NCI NIH HHS K08 CA191063NCI NIH HHS T32 CA009109
6 · The paper itself

Abstract

There has been a rapid increase in adjuvant therapies approved for treatment following surgical resection of stages III/IV melanoma. We review current indications for adjuvant therapy, which currently includes a heterogenous group of stages III and IV patients with melanoma. We describe several pivotal clinical trials of systemic immune therapies, targeted immune therapies, and adjuvant vaccine strategies. Finally, we discuss the evidence for selecting the most appropriate treatment regimen(s) for the individual patient.

Indexed as

ImmunotherapyAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantDisease ManagementHumansMelanomaPrognosisSkin Neoplasmsadjuvant therapymelanoma

Identifiers

PMID30481375
PMCPMC6330126

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.