Evidence map›Paper›PMID 30481229›Full record

ArticlePloS one2018

Association between number of children and carotid intima-media thickness in Bangladesh.

Vylyny Chat, Fen Wu, Ryan T Demmer, Faruque Parvez, Alauddin Ahmed, Mahbub Eunus, Rabiul Hasan, Jabun Nahar, Ishrat Shaheen, Golam Sarwar and 3 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Vylyny ChatDepartments of Population Health and Environmental Medicine, New York University School of Medicine, New York, New York, United States of America.
Fen WuDepartments of Population Health and Environmental Medicine, New York University School of Medicine, New York, New York, United States of America.
Ryan T DemmerDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
Faruque ParvezDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
Alauddin AhmedU-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh.
Mahbub EunusU-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh.
Rabiul HasanU-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh.
Jabun NaharU-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh.
Ishrat ShaheenU-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh.
Golam SarwarU-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh.
Moise DesvarieuxDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America.
Habibul AhsanDepartment of Health Studies, Center for Cancer Epidemiology and Prevention, The University of Chicago, Chicago, Illinois, United States of America.
Yu ChenDepartments of Population Health and Environmental Medicine, New York University School of Medicine, New York, New York, United States of America.ORCID 0000-0003-1962-5329
University of Chicago Research Bangladesh · BDNew York University · USColumbia University · USInserm · FRUniversity of Chicago · US

Funding

Training CoreP42ES010349 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NAVAS-ACIEN, ANA · 2000 to 2020
$53.6M
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX · 1985 to 2020
$26.1M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Research Design, Data, and Analytics CoreP30DK092949 · NIDDK · UNIVERSITY OF CHICAGO · PI ELBERT S. HUANG · 2011 to 2026
$10.0M
Genetic Susceptibilty to Cardiovascular Effects of Arsenic ExposureR01ES017541 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHEN, YU · 2009 to 2013
$2.6M
Enhancement and Maintenance of the HEALS cohortR24ES028532 · NIEHS · UNIVERSITY OF CHICAGO · PI AHSAN, HABIBUL · 2017 to 2022
$1.7M
NIDDK NIH HHS P30 DK092949NIEHS NIH HHS P30 ES000260NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P42 ES010349NIEHS NIH HHS R01 ES017541
6 · The paper itself

Abstract

Previous studies on the association between number of children and carotid intima-media thickness (cIMT) were limited to Western populations. Pregnancy in women is associated with physiologic changes that may influence the risk of cardiovascular disease. Comparing the association between number of children and cIMT in men and women can provide insights on whether the association may be due to pregnancy. We investigated the association between number of children and cIMT among 718 female (mean age 37.5 years) and 417 male participants (mean age 41.3 years), randomly selected from the Health Effect of Arsenic Longitudinal Study (HEALS), a population-based cohort study in Bangladesh. Multivariate linear regression was used to assess the association and to control for education attainment, history of diabetes, age, smoking, betel use, BMI, systolic blood pressure, and diastolic blood pressure. The average number of children was 4.43 for women and 3.74 for men. There were no nulliparous women. We observed a positive association between number of children and cIMT in women. Mean cIMT increased by 4.5 μm (95% CI, 0.8-8.1) per increment of one birth (P = 0.02). Compared to women with two children, cIMT in women with 4 children and ≥5 children was 23.6μm (95%CI, 2.6-44.7; P = 0.03) and 25.1 μm (95%CI, 3.5-46.6; P = 0.02) greater, respectively. The association was not modified by BMI, SBP, betel use or age. Data in men showed no evidence of association (P = 0.4). The finding suggests a role of high parity in atherosclerosis in women of a low-income, high parity population.

Indexed as

Carotid Intima-Media ThicknessAdultAtherosclerosisBangladeshCarotid Artery DiseasesChildFemaleHumansLongitudinal StudiesMaleParturitionPovertyPregnancyRisk FactorsSex Factors

Identifiers

PMID30481229
PMCPMC6258552
OpenAlexW2902815679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.