Evidence map›Paper›PMID 30481118›Full record

Observational studyMicrobial drug resistance (Larchmont, N.Y.)

Staphylococcus aureus Infecting and Colonizing Experimental Animals, Macaques, in a Research Animal Facility.

Maria Pardos de la Gandara, Leslie Diaz, Chad W Euler, Marilyn Chung, Alejandra Gonzalez, Christopher Cheleuitte, Winrich Freiwald, Alexander Tomasz, Vincent A Fischetti, Hermínia de Lencastre

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Microbial drug resistance (Larchmont, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Association of Primate Veterinarians' Guidelines for the Judicious Use of Antimicrobials.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021
    Article
  3. Article
  4. Antibiotics (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Maria Pardos de la Gandara1 Laboratory of Microbiology and Infectious Diseases, The Rockefeller University , New York, New York.
Leslie Diaz2 Comparative Bioscience Center, The Rockefeller University , New York, New York.
Chad W Euler3 Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University , New York, New York.
Marilyn Chung1 Laboratory of Microbiology and Infectious Diseases, The Rockefeller University , New York, New York.
Alejandra Gonzalez6 Laboratory of Neural Systems, The Rockefeller University , New York, New York.
Christopher Cheleuitte7 Tri-Institutional Training Program, Laboratory Animal Medicine and Science-Memorial Sloan Kettering Cancer Center, The Rockefeller University, and Weill Cornell Medicine , New York, New York.
Winrich Freiwald6 Laboratory of Neural Systems, The Rockefeller University , New York, New York.
Alexander Tomasz1 Laboratory of Microbiology and Infectious Diseases, The Rockefeller University , New York, New York.
Vincent A Fischetti3 Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University , New York, New York.
Hermínia de Lencastre1 Laboratory of Microbiology and Infectious Diseases, The Rockefeller University , New York, New York.
Rockefeller University · USInstituto de Biologia Experimental e Tecnológica · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An outbreak of methicillin-resistant Staphylococcus aureus (MRSA) infections on the skin and soft tissues of experimental macaques in the vivarium of The Rockefeller University, New York, triggered this observational and interventional study. We screened 14 macaques in the colony (samples from head, nares, and rectum) and their housing (40 environmental surfaces) four times in 1 year, for S. aureus colonization or contamination, while implementing enhanced decolonization and decontamination procedures. A total of 114 isolates of S. aureus were recovered and characterized (antibiograms, spa typing, multilocus sequence typing, pulsed-field gel electrophoresis [PFGE], mecA, Panton-Valentine Leukocidin, and arginine catabolic mobile element). Based on these results, six strains of S. aureus were identified: two MRSA strains (t16708/ST3862/PFGE-A, t16709/ST3862/PFGE-C) and one methicillin-sensitive S. aureus (t8397/ST3884/PFGE-D) were characterized for the first time in this study; strains belonging to spa types t189 and t4167 have been identified in primates in previous studies. None of these strains was common to the neighboring New York City human community. Thus, it seems probable that the animals were already colonized upon arrival to the University. We suggest screening primates for S. aureus carriage upon arrival to University vivaria and possible implementation of extensive decolonization procedures before any surgical interventions.

Indexed as

AnimalsAnti-Bacterial AgentsArginineBacterial ProteinsBacterial ToxinsElectrophoresis, Gel, Pulsed-FieldExotoxinsGenotypeHumansLeukocidinsMacacaMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMultilocus Sequence TypingNew York CityPenicillin-Binding ProteinsAnti-Bacterial AgentsArginineBacterial ProteinsBacterial ToxinsExotoxinsLeukocidinsmecA protein, Staphylococcus aureusPanton-Valentine leukocidinPenicillin-Binding ProteinsVirulence FactorsMRSAveterinary infections

Identifiers

PMID30481118
PMCPMC6350064
OpenAlexW2902105790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.