Evidence map›Paper›PMID 30480260›Full record

ArticleJournal of Alzheimer's disease reports2018

Pharmacokinetics in Rat of P8, a Peptide Drug Candidate for the Treatment of Alzheimer's Disease: Stability and Delivery to the Brain.

Nazneen N Dewji, Marc R Azar, Leah R Hanson, William H Frey Ii, Bruce H Morimoto, David Johnson

Open access · diamondAbstract read
In one paragraph

Article in Journal of Alzheimer's disease reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Nazneen N DewjiCenna Biosciences Inc., La Jolla, CA, USA.
Marc R AzarBehavioral Pharma, La Jolla, CA, USA.
Leah R HansonHealthPartners Institute, St. Paul, MN, USA.
William H Frey IiHealthPartners Institute, St. Paul, MN, USA.
Bruce H MorimotoCelerion Inc., USA.
David JohnsonMicroconstants LLC, San Diego, CA, USA.
HealthPartners · USBehavioral Pharma (United States) · USCelerion (United States) · USMicroConnex (United States) · USUniversity of California San Diego · US

Funding

Progressing the Pre-clinical development of P8 for Alzheimer's DiseaseR44AG043278 · NIA · CENNA BIOSCIENCES, INC. · PI DEWJI, NAZNEEN N · 2015 to 2021
$6.6M
Intranasal Delivery of Peptide Drugs to the BrainR43AG043278 · NIA · CENNA BIOSCIENCES, INC. · PI DEWJI, NAZNEEN N · 2012 to 2012
$262k
Small molecule therapeutics for Alzheimer's DiseaseR43AG055182 · NIA · CENNA BIOSCIENCES, INC. · PI DEWJI, NAZNEEN N · 2016 to 2016
$225k
NIA NIH HHS R43 AG043278NIA NIH HHS R43 AG055182NIA NIH HHS R44 AG043278
6 · The paper itself

Abstract

Strategies to achieve a therapy for Alzheimer's disease (AD) aimed at reducing the effects of amyloid-β (Aβ) have largely involved inhibiting or modifying the activities of the β- or

Indexed as

Alzheimer’s diseaseamyloid-βamyloid-β protein precursorAβpeptide drugpharmacokineticpresenilin

Identifiers

PMID30480260
PMCPMC6218153
OpenAlexW2891665651

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.