ArticleJournal of Alzheimer's disease reports2017
Midlife Work-Related Stress is Associated with Late-Life Gray Matter Volume Atrophy.
Article in Journal of Alzheimer's disease reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Midlife stress-related exhaustion and dementia incidence: a longitudinal study over 50 years in women.BMC psychiatry · 2024Article
- Design and overview of the Origins of Alzheimer's Disease Across the Life course (ORACLE) study.European journal of epidemiology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWork-related stress has been associated with an increased dementia risk. However, less is known about the mechanisms that underlie these associations.
objectiveThe goal is to examine associations between midlife work-related stress and late-life structural brain alterations.
methodsThe Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) study participants were randomly selected from independent population-based surveys (mean age 50) in Finland. MRI measurements included gray matter (GM) volume, white matter lesions (WML) and medial temporal atrophy (MTA) (1st re-examination,
resultsHigher levels of midlife work-related stress were associated with lower GM volume (β= -0.077,
conclusionPreviously shown associations of midlife work-related stress with dementia risk may be at least partly explained by associations with lower GM volume in late-life. The lack of associations at the second re-examination may indicate a critical time window for the effects of midlife work-related stress, and/or selective survival/participation.
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Registered trials
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