ArticleJournal of Alzheimer's disease reports2017
Aluminum Should Now Be Considered a Primary Etiological Factor in Alzheimer's Disease.
Article in Journal of Alzheimer's disease reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 88 citations in OpenAlex.
- Protective effects of alkaloidal fraction of Elaeocarpus angustifolius Blume against AlCl₃-evoked neurotoxicity: insights from an in vivo model of Alzheimer's disease.Metabolic brain disease · 2025Article
- Silicon Is Linked to Tea Quality Through Alteration Aluminum Uptake and Translocation inFoods (Basel, Switzerland) · 2025Article
- Chemical element profiling in hair of bipolar disorder patients and healthy controls.Frontiers in physiology · 2025Article
- Carcinogenic and non-carcinogenic health risk assessment of heavy metals in the offal of animals from Felele Abattoir, Lokoja, Nigeria.Toxicology reports · 2024Article
- Impact of welding occupation on serum aluminium level and its association with physical health, cognitive function, and quality of life: a cross-sectional study.International archives of occupational and environmental health · 2024Article
- Response to "Comment on 'Proton pump inhibitors and dementia: A nationwide population-based study'".Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Compositional analysis of Swertia chirayita medicinal plant using laser-induced breakdown spectroscopy and ICP-MS.PloS one · 2024Article
- Vitamin K2 protects against aluminium chloride-mediated neurodegeneration.Inflammopharmacology · 2023Article
- Dietary Egg White Hydrolysate Prevents Male Reproductive Dysfunction after Long-Term Exposure to Aluminum in Rats.Metabolites · 2022Article
- Intranasal Oxytocin Attenuates Cognitive Impairment, β-Amyloid Burden and Tau Deposition in Female Rats with Alzheimer's Disease: Interplay of ERK1/2/GSK3β/Caspase-3.Neurochemical research · 2022Article
- Bioaugmentation and bioaugmentation-assisted phytoremediation of heavy metal contaminated soil by a synergistic effect of cyanobacteria inoculation, biochar, and purslane (Portulaca oleracea L.).Environmental science and pollution research international · 2022Article
- A Review on Coordination Properties of Al(III) and Fe(III) toward Natural Antioxidant Molecules: Experimental and Theoretical Insights.Molecules (Basel, Switzerland) · 2021Review
- A Toxic Synergy between Aluminium and Amyloid Beta in Yeast.International journal of molecular sciences · 2021Article
- Aluminum-Induced Alterations in Purinergic System Parameters of BV-2 Brain Microglial Cells.Journal of immunology research · 2021Article
- Does aluminum exposure affect cognitive function? a comparative cross-sectional study.PloS one · 2021Article
- Challenges and Opportunities of Biocoagulant/Bioflocculant Application for Drinking Water and Wastewater Treatment and Its Potential for Sludge Recovery.International journal of environmental research and public health · 2020Review
- Microbial Biosurfactants in Cosmetic and Personal Skincare Pharmaceutical Formulations.Pharmaceutics · 2020Review
- Bioaugmentation ofHeliyon · 2020Article
- Up-regulation of miR-137 can inhibit PTN in target manner to regulate PTN/PTPRZ pathway to prevent cognitive dysfunction caused by propofol.American journal of translational research · 2020Article
- Intracellular Aluminium in Inflammatory and Glial Cells in Cerebral Amyloid Angiopathy: A Case Report.International journal of environmental research and public health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, I have summarized the experimental and largely clinical evidence that implicates aluminum as a primary etiological factor in Alzheimer's disease. The unequivocal neurotoxicity of aluminum must mean that when brain burdens of aluminum exceed toxic thresholds that it is inevitable that aluminum contributes toward disease. Aluminum acts as a catalyst for an earlier onset of Alzheimer's disease in individuals with or without concomitant predispositions, genetic or otherwise. Alzheimer's disease is not an inevitable consequence of aging in the absence of a brain burden of aluminum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.