Evidence map›Paper›PMID 30480161›Full record

ArticleIBRO reports2018

Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter system.

Kazue Hashimoto-Torii, Masanori Sasaki, Yu-Wen Chang, Hye Hwang, Stephen G Waxman, Jeffery D Kocsis, Pasko Rakic, Masaaki Torii

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IBRO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Long-term spatial tracking of cells affected by environmental insults.Journal of neurodevelopmental disorders · 2020
    Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kazue Hashimoto-ToriiCenter for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.
Masanori SasakiDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA.
Yu-Wen ChangDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA.
Hye HwangCenter for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.
Stephen G WaxmanDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA.
Jeffery D KocsisDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA.
Pasko RakicDepartment of Neurobiology and Kavli Institute for Neuroscience, School of Medicine, Yale University, New Haven, CT 06510, USA.
Masaaki ToriiCenter for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.
Yale University · USChildren's National · USSapporo Medical University · JP

Funding

Clinical and Translational Science Institute at Children's NationalUL1TR000075 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2012 to 2015
$13.7M
Origin of Cortical Species-specific Distinctions.R01DA023999 · NIDA · YALE UNIVERSITY · PI RAKIC, PASKO · 2008 to 2019
$7.9M
PRENATAL DEVELOPMENT OF THE VISUAL SYSTEMR01EY002593 · NEI · YALE UNIVERSITY · PI ARELLANO, JUAN I, RAKIC, PASKO · 1985 to 2018
$6.5M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9M
Role of autism-linked genes in developmental refinement of the corpus callosumR01MH111674 · NIMH · CHILDREN'S RESEARCH INSTITUTE · PI TORII, MASAAKI · 2017 to 2021
$2.4M
The roles of alcohol-inducible RNA-operons in the fetal brainR01AA025215 · NIAAA · CHILDREN'S RESEARCH INSTITUTE · PI HASHIMOTO-TORII, KAZUE · 2016 to 2020
$2.0M
Roles of Primary Cilia in the Developing Cortex Exposed to AlcoholR21AA024882 · NIAAA · CHILDREN'S RESEARCH INSTITUTE · PI HASHIMOTO-TORII, KAZUE, TORII, MASAAKI · 2017 to 2018
$459k
NCATS NIH HHS UL1 TR000075NEI NIH HHS R01 EY002593NIAAA NIH HHS R01 AA025215NIAAA NIH HHS R21 AA024882NICHD NIH HHS U54 HD090257NIDA NIH HHS R01 DA023999NIMH NIH HHS R01 MH111674
6 · The paper itself

Abstract

Spinal cord and peripheral nerve injury results in extensive damage to the locally injured cells as well as distant cells that are functionally connected to them. Both primary and secondary damage can cause a broad range of clinical abnormalities, including neuropathic pain and cognitive and memory dysfunction. However, the mechanisms underlying these abnormalities remain unclear, awaiting new methods to identify affected cells to enable examination of their molecular, cellular and physiological characteristics. Here, we report that both primary and secondary damage to cells in mouse models of spinal cord and peripheral nerve injury can be detected

Indexed as

Cellular damageDRG, dorsal root ganglionFG, Fluoro-GoldHeat shock signalingHRP, horseradish peroxidaseHSE, heat shock-response elementHSF1, heat shock factor 1HSP, heat shock proteinIL-6, interleukin 6M1, primary motor cortexM2, secondary motor cortexMPtA, medial parietal association cortexPBS, phosphate buffered salinePCR, polymerase chain reactionReporter mouseRFP, red fluorescent proteinSciatic nerve injurySCI, spinal cord injurySNI, sciatic nerve injurySpinal cord injuryWDR, wide-dynamic rangeWGA, wheat germ agglutinin

Identifiers

PMID30480161
PMCPMC6240805
OpenAlexW2900023869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.