ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2018
A very light lunch: Interoceptive deficits and food aversion at onset in a case of behavioral variant frontotemporal dementia.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Building the bodily self-awareness: Evidence for the convergence between interoceptive and exteroceptive information in a multilevel kernel density analysis study.Human brain mapping · 2020Pooled it
- Chewing and Swallowing Abilities of Persons Living With Dementia: A Systematic Review of Psychometric Properties of Instruments.Innovation in aging · 2023Review
- A predictive coding framework of allostatic-interoceptive overload in frontotemporal dementia.Trends in neurosciences · 2022Review
- Brain Neural Underpinnings of Interoception and Decision-Making in Alzheimer's Disease: A Narrative Review.Frontiers in neuroscience · 2022Review
- Atypical interoception as a common risk factor for psychopathology: A review.Neuroscience and biobehavioral reviews · 2021Review
- Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Interoceptive sensibility tunes risk-taking behaviour when body-related stimuli come into play.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPatients affected by the behavioral variant frontotemporal dementia (bvFTD) frequently experience, at a delayed onset, abnormal eating behavior involving increased food intake. Although delusional food-related symptoms have attracted much attention, the behavioral and neural features of food aversion manifestations in bvFTD remain poorly documented.
methodsWe describe the rare case of a patient with bvFTD presenting with lack of interoception for swallowing and digestion, coupled with a dramatic food aversion at onset. We also compared his MRI scan to 84 healthy individuals using a voxel-based morphometry approach.
resultsWe found gray matter density reductions involving the postcentral gyrus bilaterally, insulae, and right medial orbitofrontal cortex. DISCUSSION: Our results shed new light on the behavioral and neuroanatomical features of food aversion and interoception deficits in bvFTD, suggesting that besides orbitofrontal cortex, also a distributed system associated with interoception might play a role in such behavioral manifestation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.