Evidence map›Paper›PMID 30480039›Full record

ArticleNeurophotonics2018

Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults.

Lian He, Wesley B Baker, Daniel Milej, Venkaiah C Kavuri, Rickson C Mesquita, David R Busch, Kenneth Abramson, Jane Y Jiang, Mamadou Diop, Keith St Lawrence and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Neurophotonics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Lian HeUniversity of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.
Wesley B BakerUniversity of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.
Daniel MilejWestern University, Department of Medical Biophysics, London, Ontario, Canada.ORCID https://orcid.org/0000-0003-3173-0834
Venkaiah C KavuriUniversity of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.
Rickson C MesquitaUniversity of Campinas, Institute of Physics, Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-1945-6713
David R BuschUniversity of Texas Southwestern, Department of Neurology and Neurotherapeutics, Dallas, Texas, United States.ORCID https://orcid.org/0000-0002-9488-944X
Kenneth AbramsonUniversity of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.
Jane Y JiangUniversity of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.
Mamadou DiopWestern University, Department of Medical Biophysics, London, Ontario, Canada.ORCID https://orcid.org/0000-0003-1244-7830
Keith St LawrenceWestern University, Department of Medical Biophysics, London, Ontario, Canada.ORCID https://orcid.org/0000-0001-8022-8205
Olivia AmendoliaUniversity of Pennsylvania, Department of Neurosurgery, Perelman School of Medicine, Philadelphia, Pennsylvania, United States.ORCID https://orcid.org/0000-0002-7760-6823
Francis QuattroneUniversity of Pennsylvania, Department of Neurosurgery, Perelman School of Medicine, Philadelphia, Pennsylvania, United States.
Ramani BaluUniversity of Pennsylvania, Department of Neurosurgery, Perelman School of Medicine, Philadelphia, Pennsylvania, United States.
W Andrew KofkeUniversity of Pennsylvania, Department of Anesthesiology and Critical Care, Perelman School of Medicine, Philadelphia, Pennsylvania, United States.ORCID https://orcid.org/0000-0003-0718-3834
Arjun G YodhUniversity of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.
University of Pennsylvania · USWestern University · CALawson Health Research Institute · CAThe University of Texas Southwestern Medical Center · USUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
Diffuse Optics for Acute Stroke ManagementR01NS060653 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI YODH, ARJUN G. · 2008 to 2018
$5.5M
Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical MonitorR01NS082309 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KOFKE, W ANDREW · 2014 to 2018
$2.9M
NIBIB NIH HHS P41 EB015893NINDS NIH HHS R01 NS060653NINDS NIH HHS R01 NS082309
6 · The paper itself

Abstract

We investigate a scheme for noninvasive continuous monitoring of absolute cerebral blood flow (CBF) in adult human patients based on a combination of time-resolved dynamic contrast-enhanced near-infrared spectroscopy (DCE-NIRS) and diffuse correlation spectroscopy (DCS) with semi-infinite head model of photon propogation. Continuous CBF is obtained via calibration of the DCS blood flow index (BFI) with absolute CBF obtained by intermittent intravenous injections of the optical contrast agent indocyanine green. A calibration coefficient (

Indexed as

absolute cerebral blood flowbrain-injured patientscontinuous monitoringdiffuse correlation spectroscopytime-resolved contrast-enhanced near-infrared spectroscopy

Identifiers

PMID30480039
PMCPMC6251207
OpenAlexW2940524989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.