ArticleBDJ open2018
Transcriptomic profiling of tantalum metal implant osseointegration in osteopenic patients.
Article in BDJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- A systematic review assessing the osseoincorporation potential of trabecular dental implants: A current evidence and future directions.Journal of Indian Prosthodontic Society · 2025Pooled it
- A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties.Bioactive materials · 2024Article
- Osseointegration of Tantalum Trabecular Metal in Titanium Dental Implants: Histological and Micro-CT Study.Journal of functional biomaterials · 2023Article
- Tantalum as Trabecular Metal for Endosseous Implantable Applications.Biomimetics (Basel, Switzerland) · 2023Review
- Porous Tantalum VS. Titanium Implants: Enhanced Mineralized Matrix Formation after Stem Cells Proliferation and Differentiation.Journal of clinical medicine · 2020Article
- Bone impaction grafting with trabecular metal augments in large defects in young patients: unravelling a new perspective in surgical technique.BMC musculoskeletal disorders · 2020Article
- From the Performance to the Essence: The Biological Mechanisms of How Tantalum Contributes to Osteogenesis.BioMed research international · 2020Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe long-term success of dental implants is established by literature. Although clinically well defined, the complex genetic pathways underlying osseointegration have not yet been fully elucidated. Furthermore, patients with osteopenia/osteoporosis are considered to present as higher risk for implant failure. Porous tantalum trabecular metal (PTTM), an open-cell porous biomaterial, is suggested to present enhanced biocompatibility and osteoconductivity. The goal of this study was to evaluate the expression patterns of a panel of genes closely associated with osteogenesis and wound healing in osteopenic patients receiving either traditional titanium (Ti) or PTTM cylinders to assess the pathway of genes activation in the early phases of osseointegration. MATERIAL AND
methodsImplant cylinders made of Ti and PTTM were placed in osteopenic volunteers. At 2- and 4 weeks of healing, one Ti and one PTTM cylinder were removed from each subject for RT-PCR analysis using osteogenesis PCR array.
resultsCompared to Ti, PTTM-associated bone displayed upregulation of bone matrix proteins, BMP/TGF tisuperfamily, soluble ligand and integrin receptors, growth factors, and collagen genes at one or both time points. Histologically, PTTM implants displayed more robust osteogenesis deposition and maturity when compared to Ti implants from the same patient.
conclusionsOur results indicate that PTTM properties could induce an earlier activation of genes associated with osteogenesis in osteopenic patients suggesting that PTTM implants may attenuate the relative risk of placing dental implants in this population.
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Registered trials
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