ArticleAnnals of occupational and environmental medicine2018
Changes of hemodynamic and cerebral oxygenation after exercise in normobaric and hypobaric hypoxia: associations with acute mountain sickness.
Article in Annals of occupational and environmental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06446427 (The Effect of Acute High Altitude Exposure on Rescuer Performance and Patient Care), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Acute High Altitude Exposure on Rescuer Performance and Patient Care
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Sensitivity of cognitive function tests to acute hypoxia in healthy subjects: a systematic literature review.Frontiers in physiology · 2023Pooled it
- The effects of environmental hypoxia on substrate utilisation during exercise: a meta-analysis.Journal of the International Society of Sports Nutrition · 2019Pooled it
- The effects of normobaric and hypobaric hypoxia on cognitive performance and physiological responses: A crossover study.PloS one · 2022Trial
- MicroRNAs and genes regulating responses to hypoxia and inflammation expression levels in blood leukocytes as potential biomarkers of initial oxygen deficiency tolerance.Frontiers in molecular biosciences · 2026Article
- Morphofunctional Features of the Immune System Response to Sublethal Hypoxic Load in Hypoxia-Tolerant and Hypoxia-Susceptible Animals.Biomedicines · 2025Article
- Closing the loop: autonomous intelligent control for hypoxia pre-acclimatization and high-altitude health management.National science review · 2025Review
- Production of IL-1β and IL-10 by Blood Cells of Rats before and One Month after Sublethal Hypoxic Exposure in a Decompression Chamber.Bulletin of experimental biology and medicine · 2025Article
- Acute high-altitude illness: risk factors, susceptibility prediction, and personalized prevention and treatment.Frontiers in medicine · 2025Review
- Physiological and molecular mechanisms of tolerance to hypoxia and oxygen deficiency resistance markers.Frontiers in molecular biosciences · 2025Review
- Combining hypoxia with thermal stimuli in humans: physiological responses and potential sex differences.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Review
- Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji.Journal of physiological anthropology · 2023Article
- Contribution of Hypoxic Exercise Testing to Predict High-Altitude Pathology: A Systematic Review.Life (Basel, Switzerland) · 2022Review
- Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics.Biomedicines · 2020Review
- Hypoxic-inflammatory responses under acute hypoxia: In Vitro experiments and prospective observational expedition trial.International journal of molecular sciences · 2020Observational
- Acute Exercise in Hypobaric Hypoxia Attenuates Endothelial Shedding in Subjects Unacclimatized to High Altitudes.Frontiers in physiology · 2019Article
- Normobaric Hypoxia Exposure on Substrate Oxidation Pattern: Sex Differences.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNormobaric (NH) and hypobaric hypoxia (HH) are associated with acute mountain sickness (AMS) and cognitive dysfunction. Only few variables, like heart-rate-variability, are correlated with AMS. However, prediction of AMS remains difficult. We therefore designed an expedition-study with healthy volunteers in NH/HH to investigate additional non-invasive hemodynamic variables associated with AMS.
methodsEleven healthy subjects were examined in NH (FiO
resultsHH increased heart rate (HR), mean arterial pressure (MAP) and CI and decreased LVET, SV and ICON, whereas NH increased HR and decreased LVET. In both NH and HH cerebral oxygenation decreased and LLS increased significantly. After 24 h in HH, 6 of 11 subjects (54.6%) developed AMS. LLS remained increased until 24 h in HH, whereas cognitive function remained unaltered. In HH, HR and LLS were inversely correlated (
conclusionsBoth acute NH and HH altered hemodynamic and cerebral oxygenation and induced AMS. Subjects, who adapted their CI had higher rScO2 and lower LLS. Furthermore, rScO2 after exercise under normobaric conditions was associated with AMS at high altitudes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.