Evidence map›Paper›PMID 30479572›Full record

ArticleJournal of inflammation (London, England)2018

Circulating natural antibodies to inflammatory cytokines are potential biomarkers for atherosclerosis.

Peng Wang, Huan Zhao, Zhenqi Wang, Xuan Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Peng Wang1Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041 China.
Huan Zhao1Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041 China.
Zhenqi Wang2School of Public Health, Jilin University, Changchun, 130021 China.
Xuan Zhang1Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041 China.
Second Affiliated Hospital of Jilin University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammatory cytokines contribute to the development of atherosclerosis. Natural antibodies in the circulation have protective effects on common diseases including atherosclerosis-related conditions. PURPOSE: The present study aimed to investigate the possible involvement of circulating IgG antibodies against inflammatory cytokines in atherosclerosis.

methodsA total of 220 patients with diagnosis of atherosclerosis and 200 healthy controls were recruited. Seven linear peptide antigens were used to develop an enzyme-linked immunosorbent assay in-house for detection of plasma IgG antibodies against interleukin 1β (fragments IL1β-1 and IL1β-2), IL6, IL8, tumor necrosis factor alpha (fragments TNFα-1 and TNFα-2) and IL1α.

resultsAtherosclerotic patients had an increase in the levels of circulating IgG to TNFα-1(adjusted r

conclusionNatural antibodies to inflammatory cytokines may be potential biomarkers for atherosclerosis.

Indexed as

AtherosclerosisELISAInflammatory cytokinesNatural antibodies

Identifiers

PMID30479572
PMCPMC6240255
OpenAlexW2900780194

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.