Evidence map›Paper›PMID 30479490›Full record

ArticleJournal of experimental neuroscience2018

Unique Biology and Single-Channel Properties of GluN2A- and GluN2C-Containing Triheteromeric N-Methyl-D-Aspartate Receptors.

Subhrajit Bhattacharya, Stephen F Traynelis

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Subhrajit BhattacharyaDepartment of Pharmacology, School of Medicine, Emory University, Atlanta, GA, USA.ORCID https://orcid.org/0000-0003-1326-0699
Stephen F TraynelisDepartment of Pharmacology, School of Medicine, Emory University, Atlanta, GA, USA.
Emory University · US

Funding

Control of Glutamate Receptor FunctionR01NS036654 · NINDS · EMORY UNIVERSITY · PI TRAYNELIS, STEPHEN F · 1998 to 2018
$3.7M
Mechanism of Action of Novel Subunit-Selective NMDA Receptor ModulatorsR01NS065371 · NINDS · EMORY UNIVERSITY · PI TRAYNELIS, STEPHEN F · 2009 to 2018
$3.4M
Control of glutamate receptor functionR37NS036654 · NINDS · EMORY UNIVERSITY · PI TRAYNELIS, STEPHEN F · 2007 to 2013
$2.4M
NINDS NIH HHS R01 NS036654NINDS NIH HHS R01 NS065371NINDS NIH HHS R37 NS036654
6 · The paper itself

Abstract

Triheteromeric N-methyl-D-aspartate receptors (NMDARs) are assemblies of two different types of GluN2 subunits that endow receptors with properties distinct from their diheteromeric counterparts. Previous studies show an abundance of triheteromeric NMDARs across the central nervous system (CNS), making them an important receptor population to investigate and potential drug target. A recent study by Bhattacharya et al. (1) demonstrated the prevalence of GluN1/GluN2A/GluN2C triheteromeric NMDARs in cerebellar granule cells (CGCs), (2) suggested that GluN2C subunits seldom express as diheteromers, (3) suggested that GluN2A subunits are the preferred partners for GluN2C to functionally express at the cell surface, and (4) revealed unique single-channel properties of these triheteromeric assemblies, which may enable these cells to perform unique tasks. Taken together, this work demonstrates the physiological existence of GluN1/GluN2A/GluN2C receptors in the CGCs.

Indexed as

cerebellumGluN2C traffickingTriheteromeric NMDA receptors

Identifiers

PMID30479490
PMCPMC6247487
OpenAlexW2901197268

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.