ArticleJournal of applied biobehavioral research2018
Phenotypic Features of Central Sensitization.
Article in Journal of applied biobehavioral research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06976398 (Investigation of Central Sensitisation in Patients With Chronic Non-spesific Neck Pain), which is not on this map. Cited by 194 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of Central Sensitisation in Patients With Chronic Non-spesific Neck Pain
Who cites it
194 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- The effectiveness of psychological interventions on pain, disability, and psychological symptoms in whiplash-associated disorders: a systematic review and meta-analysis.BMC psychology · 2026Pooled it
- Migraine and Restless Legs Syndrome: A Meta-Analysis.Journal of sleep research · 2026Pooled it
- Repurposed versus disease-specific medicinals for the prophylaxis of migraine: an updated systematic review.Pain management · 2025Pooled it
- Brain-derived neurotrophic factor in fibromyalgia: A systematic review and meta-analysis of its role as a potential biomarker.PloS one · 2023Pooled it
- Tests for central sensitization in general practice: a Delphi study.BMC family practice · 2021Pooled it
- Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis.Nutrients · 2020Pooled it
- Effects of Transcranial Direct Current Stimulation and Individualized Physical Therapy on Pain and Function in Individuals With Chronic Knee Pain: A Pilot Study.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Trial
- Auditory Hyperresponsivity in Chronic Back Pain: A Randomized Controlled Trial of Pain Reprocessing Therapy.Annals of neurology · 2026Trial
- Prevalence of Chronic Overlapping Pain Conditions in Participants With Chronic Low Back Pain Enrolled in a Pragmatic Trial of Mindfulness-Based Stress Reduction.European journal of pain (London, England) · 2025Trial
- Open-Label Placebos as Adjunct for the Preventive Treatment of Migraine: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Pain Neuroscience Education and Resistance Training in Women With Fibromyalgia: A Randomized Control Pilot Study.Pain research & management · 2025Trial
- Regional vs global physical therapy interventions to treat chronic pain in survivors of trauma: a randomized controlled trial.The Journal of manual & manipulative therapy · 2023Trial
- Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial.BMC musculoskeletal disorders · 2022Trial
- Trial
- Green light exposure reduces central sensitization in cats with osteoarthritis-associated somatosensory impairment.iScience · 2026Article
- Lower resting-state functional connectivity between frontoparietal and sensory networks is associated with recent pain intensity in a community sample of youth.Neuroimage. Reports · 2026Article
- New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study.Arthritis care & research · 2026Article
- The Mediating Role of Negative Affect in the Relationship Between Anger Rumination and Somatic Symptoms.Actas espanolas de psiquiatria · 2026Article
- Meditations on Methodological Issues in Clinical Investigations of "Central Sensitization" (Jonah XII).Journal of clinical medicine · 2026Article
- Chronic Ocular Surface Pain: A Missing Member of the Chronic Overlapping Pain Conditions?Drugs · 2026Review
134 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
purposeThe current manuscript reviews approaches for phenotyping central sensitization (CS).
methodsThe manuscript covers the concept of diagnostic phenotyping, use of endophenotypes, biomarkers, and symptom clusters. Specifically, the components of CS that include general sensory sensitivity (assessed by quantitative sensory testing) and a symptom cluster denoting sleep difficulties, pain, affect, cognitive difficulties, and low energy (S.P.A.C.E.).
resultsEach of the assessment domains are described with reference to CS and their presence in chronic overlapping pain conditions (COPCs) - conditions likely influenced by CS.
conclusionsCOPCs likely represent clinical diagnostic phenotypes of CS. Components of CS can also be assessed using QST or self-report instruments designed to assess single elements of CS or more general composite indices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.