ArticleNature communications2018
Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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Who cites it
73 citing papers in PubMed, 137 citations in OpenAlex.
- Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026Review
- N-cadherin orientational order decreases with mechanical load at cardiomyocyte adherens junctions.bioRxiv : the preprint server for biology · 2026Article
- Single Cell Mechanics in Disease Progression.Small science · 2026Review
- DNA-PAINT resolves E-cadherin-independent cross-junctional F-actin organization in Drosophila embryonic tissue.Biophysical journal · 2026Article
- Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025Article
- Repeated extrinsic and anisotropic mechanical inputs promote C. elegans polarized adherens junction elongation.Developmental cell · 2025Article
- Planer-polarized junction association of the RacGEF ELMO-Sponge contributes to planar polarity and germband extension in Drosophila embryos.Science China. Life sciences · 2025Article
- Force transmission is a master regulator of mechanical cell competition.Nature materials · 2025Article
- Rectification of planar orientation angle switches behavior and replenishes contractile junctions.The Journal of cell biology · 2025Article
- Tissue stiffness mapping by light sheet elastography.Science advances · 2025Article
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- Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing.Nature communications · 2025Article
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- Nuclei as mechanical bumpers during epithelial remodeling.The Journal of cell biology · 2024Article
- Regulation of epithelial cell jamming transition by cytoskeleton and cell-cell interactions.Biophysics reviews · 2024Review
- Different Biomechanical Cell Behaviors in an Epithelium Drive Collective Epithelial Cell Extrusion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
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- Conserved physical mechanisms of cell and tissue elongation.Development (Cambridge, England) · 2024Review
- The Geometric Basis of Epithelial Convergent Extension.bioRxiv : the preprint server for biology · 2024Article
- Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal role in this process by providing persistent cell adhesion and by transmitting mechanical tension. In this context, it is unclear how mechanical forces affect E-cadherin adhesion and junction dynamics. During Drosophila embryo axis elongation, Myosin-II activity in the apico-medial and junctional cortex generates mechanical forces to drive junction remodeling. Here we report that the ratio between Vinculin and E-cadherin intensities acts as a ratiometric readout for these mechanical forces (load) at E-cadherin complexes. Medial Myosin-II loads E-cadherin complexes on all junctions, exerts tensile forces, and increases levels of E-cadherin. Junctional Myosin-II, on the other hand, biases the distribution of load between junctions of the same cell, exerts shear forces, and decreases the levels of E-cadherin. This work suggests distinct effects of tensile versus shear stresses on E-cadherin adhesion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.