ArticleScientific reports2018
Flavonoids are identified from the extract of Scutellariae Radix to suppress inflammatory-induced angiogenic responses in cultured RAW 264.7 macrophages.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antiangiogenic Activity of Flavonoids: A Systematic Review and Meta-Analysis.Molecules (Basel, Switzerland) · 2020Pooled it
- Natural metabolites targeting macrophage polarization for non-small cell lung cancer therapy: a review of mechanisms and applications based on chemical classification.Frontiers in pharmacology · 2026Review
- Nepetin Attenuates Atopic Dermatitis in HaCaT Cells and BALB/c Mice through MyD88-MKK3/6-Akt Signaling.Current medicinal chemistry · 2025Article
- Unveiling the power of flavonoids: A dynamic exploration of their impact on cancer through matrix metalloproteinases regulation.BioMedicine · 2024Review
- Biotechnological strategies for controlled accumulation of flavones in hairy root culture of Scutellaria lateriflora L.Scientific reports · 2023Article
- Ethanol extract of basil (Journal of medicine and life · 2023Article
- Phytochemical Profiling and Bio-Potentiality of GenusBiomolecules · 2022Review
- Zhuanggu Guanjie herbal formula mitigates osteoarthritisFrontiers in pharmacology · 2022Article
- Scutellariae Radix and Citri Reticulatae Pericarpium Mixture Regulate PPAREvidence-based complementary and alternative medicine : eCAM · 2022Article
- Tanreqing Injection Attenuates Macrophage Activation and the Inflammatory ResponseFrontiers in immunology · 2022Article
- Antibacterial Modes of Herbal Flavonoids Combat Resistant Bacteria.Frontiers in pharmacology · 2022Review
- Characterization of a macrophagic-like cell line derived from rabbit fish (Fish and shellfish immunology reports · 2021Article
- Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression-3PM pathways.The EPMA journal · 2021Review
- Inhibition of Virulence Factors and Biofilm Formation by Wogonin Attenuates Pathogenicity ofInternational journal of molecular sciences · 2021Article
- Assessment of Anti-Inflammatory and Antioxidant Effects ofPlants (Basel, Switzerland) · 2021Article
- Article
- Screening of Anti-Inflammatory Components of Qin Jin Hua Tan Tang by a Multivariate Statistical Analysis Approach for Spectrum-Effect Relationships.Journal of analytical methods in chemistry · 2021Article
- Network Pharmacology-Based Prediction of Bioactive Compounds and Potential Targets of Wenjing Decoction for Treatment of Endometriosis.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Pharmaceutical Values of Calycosin: One Type of Flavonoid Isolated fromEvidence-based complementary and alternative medicine : eCAM · 2021Review
- The herbal extract deriving from aerial parts of Scutellaria baicalensis shows anti-inflammation and anti-hypoxia responses in cultured fin cells from rabbit fish.Fish & shellfish immunology · 2020Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Scutellariae Radix (SR), also named Huangqin in China, is the dried root of Scutellaria baicalensis Georgi. Historically, the usage of SR was targeted to against inflammation. In fact, chronic inflammation has a close relationship with hypoxia and abnormal angiogenesis in tumor cells. Hence, we would like to probe the water extract of SR in suppressing the inflammation-induced angiogenesis. Prior to determine the pharmaceutical values of SR, the first step is to analysis the chemical compositions of SR according to China Pharmacopeia (2015). From the results, the amount of baicalin was 12.6% by weight. Furthermore, the anti-angiogenic properties of SR water extract were evaluated in lipopolysaccharide (LPS) pre-treated cultured macrophage RAW 264.7 cells by detecting the inflammatory markers, i.e. Cox-2, cytokine and iNOS, as well as the translocation activity of NFκB and angiogenic biomarker, i.e. VEGF. This herbal extract was capable of declining both inflammatory and angiogenic hallmarks in a concentration-dependent manner. Moreover, the SR-derived flavonoids, i.e. baicalin, baicalein, wogonin and wogonoside, were shown to be active chemicals in the anti-inflammatory-induced angiogenesis. Therefore, the inflammation-induced angiogenesis is believed to be suppressed by SR water extract, or its major ingredients. These results shed light in the benefiting role of SR in the inflammation-induced angiogenesis in vitro.
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