Evidence map›Paper›PMID 30479187›Full record

Trial reportHematology (Amsterdam, Netherlands)2019

Risk factors for hospitalizations and readmissions among individuals with sickle cell disease: results of a U.S. survey study.

Robert M Cronin, Jane S Hankins, Jeannie Byrd, Brandi M Pernell, Adetola Kassim, Patricia Adams-Graves, Alexis Thompson, Karen Kalinyak, Michael DeBaun, Marsha Treadwell

Abstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hematology (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  6. Buprenorphine Is Associated With Lower Home Opioid Use and Acute Care Utilization in Sickle Cell Disease.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Robert M Cronina Department of Biomedical Informatics , Vanderbilt University Medical Center , Nashville , TN , USA.ORCID http://orcid.org/0000-0003-1916-6521
Jane S Hankinsd Department of Hematology , St Jude Children's Research Hospital , Memphis , TN , USA.
Jeannie Byrde Department of Pediatrics, Division of Hematology/Oncology, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease , Vanderbilt University Medical Center , Nashville , TN , USA.
Brandi M Pernelle Department of Pediatrics, Division of Hematology/Oncology, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease , Vanderbilt University Medical Center , Nashville , TN , USA.
Adetola Kassimg Department of Hematology/Oncology , Vanderbilt University Medical Center , Nashville , TN , USA.
Patricia Adams-Gravesh Department of General Internal Medicine and Hematology , University of Tennessee Health Science Center , Memphis , TN , USA.
Alexis Thompsoni Department of Pediatrics, Department of Medicine , Northwestern University , Chicago , IL , USA.
Karen Kalinyakj Division of Hematology in Cancer and Blood Diseases Institute , University of Cincinnati , Cincinnati , OH , USA.
Michael DeBaune Department of Pediatrics, Division of Hematology/Oncology, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease , Vanderbilt University Medical Center , Nashville , TN , USA.
Marsha Treadwellk Department of Hematology/Oncology , UCSF Benioff Children's Hospital Oakland , Oakland , CA , USA.ORCID http://orcid.org/0000-0003-0521-1846

Funding

Using Patient-Centered Guidelines in a Technology Platform to Improve Health Care in Adults with Sickle Cell DiseaseK23HL141447 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CRONIN, ROBERT M · 2018 to 2022
$921k
NHLBI NIH HHS K23 HL141447
6 · The paper itself

Abstract

objectiveHospital admissions are significant events in the care of individuals with sickle cell disease (SCD) due to associated costs and potential for quality of life compromise.

methodsThis cross-sectional cohort study evaluated risk factors for admissions and readmissions between October 2014 and March 2016 in adults with SCD (n = 201) and caregivers of children with SCD (n = 330) at six centres across the U.S. Survey items assessed social determinants of health (e.g. educational attainment, difficulty paying bills), depressive symptoms, social support, health literacy, spirituality, missed clinic appointments, and outcomes hospital admissions and 30-day readmissions in the previous year.

resultsA majority of adults (64%) and almost half of children (reported by caregivers: 43%) were admitted, and fewer readmitted (adults: 28%; children: 9%). The most common reason for hospitalization was uncontrolled pain (admission: adults: 84%, children: 69%; readmissions: adults: 83%, children: 69%). Children were less likely to have admissions/readmissions than adults (Admissions: OR: 0.35, 95% CI: [0.23,0.52]); Readmissions: 0.23 [0.13,0.41]). For all participants, missing appointments were associated with admissions (1.66 [1.07, 2.58]) and readmissions (2.68 [1.28, 6.29]), as were depressive symptoms (admissions: 1.36 [1.16,1.59]; readmissions: 1.24 [1.04, 1.49]). In adults, difficulty paying bills was associated with more admissions, (3.11 [1.47,6.62]) readmissions (3.7 [1.76,7.79]), and higher spirituality was associated with fewer readmissions (0.39 [0.18,0.81]). DISCUSSION: Missing appointments was significantly associated with admissions and readmissions. Findings confirm that age, mental health, financial insecurity, spirituality, and clinic attendance are all modifiable factors that are associated with admissions and readmissions; addressing them could reduce hospitalizations.

Indexed as

Patient ReadmissionAdolescentAdultAge FactorsAnemia, Sickle CellChildCross-Sectional StudiesFemaleHumansMaleMental HealthSocioeconomic FactorsUnited Statesclinic visitshealth care surveysHealth care utilizationhospital admissionssickle cell diseasevulnerable populations

Identifiers

PMID30479187
PMCPMC6349225

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.