ArticleAllergy, asthma & immunology research2019
Prevalence and Clinical Features of Drug Reactions With Eosinophilia and Systemic Symptoms Syndrome Caused by Antituberculosis Drugs: A Retrospective Cohort Study.
Article in Allergy, asthma & immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The Use of Electronic Health Records to Study Drug-Induced Hypersensitivity Reactions from 2000 to 2021: A Systematic Review.Immunology and allergy clinics of North America · 2022Pooled it
- Utility of Patch Testing, LTT, and HLA Genotyping in Identifying Culprit Drugs and Diagnosing Multiple Drug Hypersensitivity in Definite DRESS: A 10-Year Cohort Study.Clinical and translational allergy · 2026Article
- Insights into Severe Cutaneous Adverse Drug Reactions: A 5-Year Retrospective Analysis of Stevens- Johnson Syndrome- Toxic Epidermal Necrolysis and Drug Rash with Eosinophilia and Systemic Symptoms.Indian dermatology online journal · 2026Article
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Retrospective Study of 51 Chinese Patients.Clinical, cosmetic and investigational dermatology · 2025Article
- Drug Reaction with Eosinophilia and Systemic Symptoms Secondary to Ethambutol.Journal of Brown hospital medicine · 2025Article
- Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report.Therapeutic advances in drug safety · 2025Article
- Non-episodic angioedema with eosinophilia as a differential diagnosis of eosinophilia in young females.The World Allergy Organization journal · 2024Article
- Delayed drug hypersensitivity to anti-tuberculosis drug: a new desensitization scheme.Postepy dermatologii i alergologii · 2024Article
- Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome secondary to antimicrobial therapy in pediatric bone and joint infections.The World Allergy Organization journal · 2024Article
- Drug reaction with eosinophilia and systemic symptoms syndrome secondary to isoniazid and ethambutol: a case report and literature review.Annals of medicine and surgery (2012) · 2023Article
- Lack of Suspicion of Dapsone Hypersensitivity Syndrome in a Leprosy Patient: Case Report with Fatal Outcome.Research and reports in tropical medicine · 2023Article
- DRESS characteristics according to the causative medication.European journal of clinical pharmacology · 2022Article
- Case Report: DRESS Syndrome Induced by Two Antituberculosis Drugs in an 8-Year-Old Girl.Frontiers in pediatrics · 2022Article
- Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review.European journal of clinical pharmacology · 2021Review
- Severe Cutaneous Adverse Reactions Caused by Anti-Tubercular Drugs.Allergy, asthma & immunology research · 2021Article
- Severe Cutaneous Adverse Reactions in Korean Pediatric Patients: A Study From the Korea SCAR Registry.Allergy, asthma & immunology research · 2019Article
- DRESS syndrome: an interaction between drugs, latent viruses, and the immune system.Anais brasileiros de dermatologiaReview
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough there have been reported cases of drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome caused by antituberculosis drugs, there has been no research to examine its prevalence. This study assessed the prevalence and clinical characteristics of DRESS syndrome caused by antituberculosis drugs.
methodsThe electronic medical records of a cohort consisting of adult patients diagnosed with tuberculosis between July 2006 and June 2010 were reviewed and retrospectively inspected. We searched the surveillance system for adverse drug reactions and the electronic medical records to identify patients who reported severe cutaneous adverse reactions to antituberculosis drugs. These patients were then re-assessed using a European Registry of Severe Cutaneous Adverse Reactions to Drugs and Collection of Biological Samples (RegiSCAR) scoring system. Clinical characteristics, including the symptoms and latency of DRESS syndrome, the therapeutic dosage and period of steroids, and the final duration of tuberculosis therapy, were examined.
resultsOf the 1,253 adult patients with tuberculosis receiving antituberculosis drugs, 15 were identified as potential cases of DRESS syndrome (prevalence of 1.2%). Ethambutol was the most frequently used drug (53.5%), followed by rifampicin (26.7%), pyrazinamide (20.0%), streptomycin (13.3%), and isoniazid (6.7%). The median latency after day 1 of antituberculosis medication was 42 days. The median daily dose of steroids, expressed in prednisone-equivalent units, was 33-mg/day, and the median dosing period was 14 days. The duration of tuberculosis treatment was 76 days longer than the standard treatment period of 180 days. There was a significant difference in the peak eosinophil counts of DRESS syndrome patients according to RegiSCAR scores. Moreover, there was a significant quantitative correlation between the RegiSCAR score and peak eosinophil count. A negative correlation was also found between the RegiSCAR score and latency.
conclusionsThis study confirmed the prevalence of DRESS syndrome in a cohort of adult patients with tuberculosis.
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