ArticleAllergy, asthma & immunology research2019
Characteristics of Adult Severe Refractory Asthma in Korea Analyzed From the Severe Asthma Registry.
Article in Allergy, asthma & immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Understanding disease burden, challenges in current treatment strategies and call for action for management of severe asthma in Asia: a position statement from Asian respiratory experts.Frontiers in allergy · 2026Review
- Characteristics of Severe Asthma in the Elderly: Observations From the Korean Severe Asthma Registry (KoSAR).Allergy, asthma & immunology research · 2024Article
- Biologics in Severe Asthma: An Ideal Choice for Achieving Control.Allergy, asthma & immunology research · 2024Article
- Work-related asthma in adults with severe asthma from the Korean Severe Asthma Registry (KoSAR).The World Allergy Organization journal · 2024Article
- Disease Burden and Access to Biologic Therapy in Patients with Severe Asthma, 2017-2022: An Analysis of the International Severe Asthma Registry.Journal of asthma and allergy · 2024Article
- Development and linguistic validation of the Korean version of the Severe Asthma Questionnaire.Journal of thoracic disease · 2023Article
- Article
- Phenotype of Asthma-COPD Overlap in COPD and Severe Asthma Cohorts.Journal of Korean medical science · 2022Article
- Clinical Characteristics and Disease Burden of Severe Asthma According to Oral Corticosteroid Dependence: Real-World Assessment From the Korean Severe Asthma Registry (KoSAR).Allergy, asthma & immunology research · 2022Article
- Biologics in severe asthma: the role of real-world evidence from registries.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- The Korean Severe Asthma Registry (KoSAR): real world research in severe asthma.The Korean journal of internal medicine · 2022Review
- Impact of Wearing Face Masks on Patients with Severe Asthma During the COVID-19 Pandemic.Journal of asthma and allergy · 2022Article
- Risk factors for severe adult-onset asthma: a multi-factor approach.BMC pulmonary medicine · 2021Article
- Effect of omalizumab as add-on therapy to Quality of Life Questionnaire for Korean Asthmatics (KAQLQ) in Korean patients with severe persistent allergic asthma.The Korean journal of internal medicine · 2021Article
- Risk Factors Predicting Severe Asthma Exacerbations in Adult Asthmatics: A Real-World Clinical Evidence.Allergy, asthma & immunology research · 2021Article
- Patients' experiences of asthma exacerbation and management: a qualitative study of severe asthma.ERJ open research · 2021Article
- Efficacy and safety of mepolizumab in Korean patients with severe eosinophilic asthma from the DREAM and MENSA studies.The Korean journal of internal medicine · 2021Article
- Sex Differences in Severe Asthma: Results From Severe Asthma Network in Italy-SANI.Allergy, asthma & immunology research · 2021Article
- Evaluation and Management of Difficult-to-Treat and Severe Asthma: An Expert Opinion From the Korean Academy of Asthma, Allergy and Clinical Immunology, the Working Group on Severe Asthma.Allergy, asthma & immunology research · 2020Review
- Management of Severe Asthma During the COVID-19 Pandemic in Korea.Allergy, asthma & immunology research · 2020Article
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Authors and funding
26 authors.
Funding
Abstract
purposeAlthough mild to moderate asthma is much more common, the morbidity and mortality of severe asthma are much higher. This study was performed to identify and analyze the clinical characteristics of severe asthma in Korea.
methodsWe registered patients with severe refractory asthma into the Severe Asthma Registry supported by the Severe Asthma Work Group of the Korean Academy of Asthma, Allergy and Clinical Immunology. Patients were enrolled since 2010 from the 15 university hospitals nationwide in Korea. Severe asthma was defined according to modified European Respiratory Society/American Thoracic Society criteria. Information on demographics, medical history, pulmonary function tests and skin prick tests was collected; the clinical characteristics of severe asthmatics were analyzed from the collected data.
resultsA total of 489 patients were enrolled with a mean age of 62.3; 45% are male. Sixty percent of patients received Global Initiative for Asthma step 4 treatment, and 30% received step 5 treatment. The most common comorbidities were allergic rhinitis (58.7%). Aspirin hypersensitivity was observed in 14.0%. Approximately half (53.9%) are non-smokers. Atopy was proven in 38.5% of the patients. Regarding asthma medications, inhaled corticosteroids and long-acting β-agonist combination inhalers were most commonly prescribed (96.5%), followed by leukotriene antagonists (71.0%). A recombinant anti-immunoglobulin E monoclonal antibody (omalizumab) has been used in 1.8% of the patients. The mean forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and FEV1/FVC were 78.7%, 67.5% and 67.9% of predicted values, respectively. The mean Asthma Control Test and quality of life questionnaire scores were 16.5 out of 25 and 59.5 out of 85, respectively.
conclusionsThe baseline characteristics of severe asthma patients in the Korea Severe Asthma Registry were analyzed and reported for the first time. With this cohort, further prospective studies should be performed to search for ways to improve management of severe refractory asthma.
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