Evidence map›Paper›PMID 30479073›Full record

ReviewAllergy, asthma & immunology research2019

Mechanisms by Which Atopic Dermatitis Predisposes to Food Allergy and the Atopic March.

Elizabeth Huiwen Tham, Donald Ym Leung

Open access · hybridAbstract readReview
In one paragraph

Review in Allergy, asthma & immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Skin barrier-related genes in childhood atopic dermatitis, asthma, and allergy: A systematic review and meta-analysis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Pooled it
  2. Pooled it
  3. Review
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  5. Article
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  9. Early-Life Allergen Exposure and Its Influence on Risk of Atopic Disease.The journal of allergy and clinical immunology. In practice · 2025
    Review
  10. Review
  11. Article
  12. Atopic dermatitis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024
    Review
  13. Article
  14. Oral Administration ofAllergy, asthma & immunology research · 2024
    Article
  15. Sociodemographic factors linked to food allergy diagnosis among high-risk children with atopic dermatitis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Elizabeth Huiwen ThamDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID https://orcid.org/0000-0003-1037-6143
Donald Ym LeungDepartment of Pediatrics, National Jewish Health, Denver, CO, USA.ORCID https://orcid.org/0000-0002-0177-3844
Denver Health Medical Center · USNational University of Singapore · SG

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
Targeted Microbiome Transplant in Atopic DermatitisU19AI117673 · NIAID · NATIONAL JEWISH HEALTH · PI GALLO, RICHARD L · 2015 to 2019
$30.6M
THE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASER01AR041256 · NIAMS · NATIONAL JEWISH HEALTH · PI GOLEVA, ELENA, LEUNG, DONALD YM · 1992 to 2020
$5.9M
NCRR NIH HHS UL1 RR025780NIAID NIH HHS U19 AI117673NIAMS NIH HHS R01 AR041256NIH HHS 1U19AI117673NIH HHS R01AR41256NIH HHS UL1RR025780
6 · The paper itself

Abstract

The Atopic march denotes the progression from atopic dermatitis (AD) to the development of other allergic disorders such as immunoglobulin (Ig) E-mediated food allergy, allergic rhinitis and asthma in later childhood. There is increasing evidence from prospective birth cohort studies that early-onset AD is a risk factor for other allergic diseases or is found in strong association with them. Animal studies now provide mechanistic insights into the pathways that may be responsible for triggering the progression from the skin barrier dysfunction seen in AD to epicutaneous sensitization, food allergy and allergic airway disorders. Recent large randomized controlled trials have demonstrated the efficacy of early interventions targeted at AD and food allergy prevention. These show great promise for research into future strategies aimed at prevention of the atopic march.

Indexed as

allergic rhinitis, asthma, food allergyatopic dermatitisAtopic march

Identifiers

PMID30479073
PMCPMC6267189
OpenAlexW2902615676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.