Evidence map›Paper›PMID 30478956›Full record

ArticleESC heart failure2019

Possible mechanism for disposal of degenerative cardiomyocytes in human failing hearts: phagocytosis by a neighbour.

Genzou Takemura, Kenji Onoue, Tomoya Nakano, Takuya Nakamura, Yasuhiro Sakaguchi, Akiko Tsujimoto, Nagisa Miyazaki, Takatomo Watanabe, Hiromitsu Kanamori, Hideshi Okada and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Genzou TakemuraDepartment of Internal Medicine, Asahi University School of Dentistry, Mizuho, Japan.
Kenji OnoueDepartment of Cardiovascular Medicine, Nara Medical University, Kashihara, Japan.
Tomoya NakanoDepartment of Cardiovascular Medicine, Nara Medical University, Kashihara, Japan.
Takuya NakamuraDepartment of Cardiovascular Medicine, Nara Medical University, Kashihara, Japan.
Yasuhiro SakaguchiDepartment of Cardiovascular Medicine, Nara Medical University, Kashihara, Japan.
Akiko TsujimotoDepartment of Cardiology, Gifu University School of Medicine, Gifu, Japan.
Nagisa MiyazakiDepartment of Internal Medicine, Asahi University School of Dentistry, Mizuho, Japan.
Takatomo WatanabeDepartment of Cardiology, Gifu University School of Medicine, Gifu, Japan.
Hiromitsu KanamoriDepartment of Cardiology, Gifu University School of Medicine, Gifu, Japan.
Hideshi OkadaDepartment of Emergency and Disaster Medicine, Gifu University School of Medicine, Gifu, Japan.
Masanori KawasakiDepartment of Cardiology, Gifu University School of Medicine, Gifu, Japan.
Takako FujiwaraHyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.
Hisayoshi FujiwaraHyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.
Yoshihiko SaitoDepartment of Cardiovascular Medicine, Nara Medical University, Kashihara, Japan.
Gifu University · JPNara Medical University · JPHyogo Prefectural Amagasaki General Medical Center · JPAsahi University · JPMizuho (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The index case was a 51-year-old woman suffering from doxorubicin cardiomyopathy. In her endomyocardial biopsy specimen, we observed under electron microscopy six scenes in which degenerative cardiomyocytes were engulfed by neighbouring cardiomyocytes. The enclosed cardiomyocytes appeared more degenerative than the enclosing ones in every pair: the myofibrils were more severely damaged. At more degenerative stages, some desmosomes of the intercalated discs on the enclosed cardiomyocyte had disappeared. The membranes between the cardiomyocytes were occasionally disrupted, and there appeared to be sharing of cellular contents between the cells. One pair of such a phagocytosis-like figure was observed in one case with 5-fluorouracil cardiomyopathy (a 68-year-old man) among eight other chemotherapy-induced cardiomyopathies but none among 30 non-drug-induced dilated cardiomyopathies. The findings suggest a mechanism for disposal of degenerative cardiomyocytes in human failing hearts: phagocytosis by a neighbour, although alternative interpretations remain (e.g. giant autophagic vacuoles or two cardiomyocytes with degenerative intercalated discs).

Indexed as

AdultAgedBiopsyCardiomyopathiesFemaleHeart FailureHumansMaleMicroscopy, ElectronMiddle AgedMyocardiumMyocytes, CardiacPhagocytosisCardiomyopathyChemotherapyEndomyocardial biopsyHeart failurePhagocytosisUltrastructure

Identifiers

PMID30478956
PMCPMC6351884
OpenAlexW2902492891

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.