ArticleEpilepsia2019
Epidemiology of status epilepticus in adults: A population-based study on incidence, causes, and outcomes.
Article in Epilepsia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07689084 (Implementation of a Training Program to Improve EEG Competence in Neurocritical Care Nursing and Non-Physician Treatment Teams for the Recognition of Epileptiform and Ictal Patterns), which is not on this map. Cited by 93 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implementation of a Training Program to Improve EEG Competence in Neurocritical Care Nursing and Non-Physician Treatment Teams for the Recognition of Epileptiform and Ictal Patterns (EPI-TRAIN: EEG Training for the Detection of Pathological Ictal Patterns in Neurocritical Care)
Who cites it
93 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Surgical management of status epilepticus: A systematic review.Epilepsia open · 2024Pooled it
- Neuromodulation in new-onset refractory status epilepticus.Frontiers in neurology · 2023Pooled it
- Unraveling the enigma of new-onset refractory status epilepticus: a systematic review of aetiologies.European journal of neurology · 2022Pooled it
- Intravenous Brivaracetam in the Treatment of Status Epilepticus: A Systematic Review.CNS drugs · 2019Pooled it
- Chronological Sequence of Convulsive Status Epilepticus Treatment Steps in a Real-Life Scenario for Patients Enrolled in a Large Multicenter Trial.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Trial
- Development and validation of a nomogram to provide individualized predictions of functional outcomes in patients with convulsive status epilepticus at 3 months: The modified END-IT tool.CNS neuroscience & therapeutics · 2023Trial
- A Predictive Model for Short-Term Mortality After Status Epilepticus: The ACARD Score.Neurology · 2026Article
- Disease spectrum of nonconvulsive status epilepticus in children: A study based on clinical subtype characteristics and prognostic stratification.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- CT perfusion abnormalities in status epilepticus: associations with clinical characteristics, EEG, and outcome measures.Journal of neurology · 2026Article
- Defining the end point of status epilepticus: A scoping review and framework for standardization.Epilepsia · 2026Article
- Structured EEG report complements the prognostic stratification of status epilepticus.Journal of neurology · 2026Article
- Timing of Peri-Ictal MRI Abnormalities in Status Epilepticus - One Size Does Not Fit All.Annals of neurology · 2026Article
- Functional connectivity in electroencephalography of brain tumor patients in status epilepticus: a retrospective evaluation of prognostic value.Quantitative imaging in medicine and surgery · 2026Article
- Incidence, mortality, and management of status epilepticus from 2012 to 2022: An 11-year nationwide study.Epilepsia · 2026Article
- Evaluation and comparison of mortality scores in status epilepticus patients.BMC neurology · 2025Article
- Underdosing and response to pharmacotherapy in patients with status epilepticus: a retrospective study from Saudi Arabia.Annals of medicine · 2025Article
- The impact of revised definitions on the epidemiology of status epilepticus: A population-based study.Epilepsia · 2025Article
- Diagnosis, treatment, and outcome prediction of non-convulsive status epilepticus in unconscious patients in intensive care units.Neurological research and practice · 2025Review
- Bcl-2 and FAS as Apoptosis-Related Markers in Patients with Convulsive Status Epilepticus.Journal of clinical medicine · 2025Article
- Guidelines adherence in status epilepticus first steps treatment: factors associated with non-compliance and effect on outcome.Journal of neurology · 2025Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
17 authors.
Funding
Abstract
objectiveIn 2015, the International League Against Epilepsy (ILAE) proposed a new definition of status epilepticus (SE): 5 minutes of ongoing seizure activity to diagnose convulsive SE (CSE, ie, bilateral tonic-clonic SE) and 10 minutes for focal SE and absence SE, rather than the earlier criterion of 30 minutes. Based on semiology, several types of SE with prominent motor phenomena at any time (including CSE) were distinguished from those without (ie, nonconvulsive SE, NCSE). We present the first population-based incidence study applying the new 2015 ILAE definition and classification of SE and report the impact of the evolution of semiology and level of consciousness (LOC) on outcome.
methodsWe conducted a retrospective population-based incidence study of all adult patients with SE residing in the city of Salzburg between January 2011 and December 2015. Patients with hypoxic encephalopathy were excluded. SE was defined and classified according to the ILAE 2015.
resultsWe identified 221 patients with a median age of 69 years (range 20-99 years). The age- and sex-adjusted incidence of a first episode of SE, NCSE, and SE with prominent motor phenomena (including CSE) was 36.1 (95% confidence interval [CI] 26.2-48.5), 12.1 (95% CI 6.8-20.0), and 24.0 (95% CI 16.0-34.5; including CSE 15.8 [95% CI 9.4-24.8]) per 100 000 adults per year, respectively. None of the patients whose SE ended with or consisted of only bilateral tonic-clonic activity died. In all other clinical presentations, case fatality was lower in awake patients (8.2%) compared with patients with impaired consciousness (33%). SIGNIFICANCE: This first population-based study using the ILAE 2015 definition and classification of SE found an increase of incidence of 10% compared to previous definitions. We also provide epidemiologic evidence that different patterns of status evolution and LOCs have strong prognostic implications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.