ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019
Early Skeletal Muscle Loss in Non-Small Cell Lung Cancer Patients Receiving Chemoradiation and Relationship to Survival.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pre-Therapeutic Sarcopenia among Cancer Patients: An Up-to-Date Meta-Analysis of Prevalence and Predictive Value during Cancer Treatment.Nutrients · 2023Pooled it
- Prognostic value of myosteatosis in patients with lung cancer: a systematic review and meta-analysis.International journal of clinical oncology · 2022Pooled it
- Relationship between Nutritional Status and Clinical Outcome in Patients Treated for Lung Cancer.Nutrients · 2021Pooled it
- Validity and Feasibility of the Constant-Load Cycle Endurance Test in Lung Cancer Patients Undergoing Radiation Therapy.Thoracic cancer · 2026Article
- HyperSightRadiation oncology (London, England) · 2026Article
- Co-Designing Lung Cancer Rehabilitation Services for People Treated With Immunotherapy.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- Prognostic impact of sarcopenia on 5-year overall and progression-free survival in lung cancer patients: a prospective cohort study.Frontiers in nutrition · 2026Article
- Low expression of SGCA promotes lung squamous cell carcinoma malignant progression.Scientific reports · 2025Article
- Evaluation of nutritional parameters that may be associated with survival in patients with locally advanced non-small cell lung carcinoma receiving definitive concurrent chemoradiotherapy: retrospective study conducted in a tertiary pulmonary hospital.Japanese journal of radiology · 2025Article
- Body composition alterations in patients with lung cancer.American journal of physiology. Cell physiology · 2025Review
- Sarcopenic obesity in cancer.Radiology and oncology · 2024Review
- Living with low muscle mass and its impact throughout curative treatment for lung cancer: A qualitative study.PloS one · 2024Article
- Skeletal muscle adaptations in patients with lung cancer: Longitudinal observations from the whole body to cellular level.Journal of cachexia, sarcopenia and muscle · 2023Article
- Low muscle mass, malnutrition, sarcopenia, and associations with survival in adults with cancer in the UK Biobank cohort.Journal of cachexia, sarcopenia and muscle · 2023Article
- Rehabilitation outcomes for people with lung cancer (UNITE): protocol for the development of a core outcome set.BMJ open respiratory research · 2023Article
- The Modulation of Adipokines, Adipomyokines, and Sleep Disorders on Carcinogenesis.Journal of clinical medicine · 2023Review
- Current Insights in Nutrition Assessment and Intervention for Malnutrition or Muscle Loss in People with Lung Cancer: A Narrative Review.Advances in nutrition (Bethesda, Md.) · 2022Review
- Cancer, Phase Angle and Sarcopenia: The Role of Diet in Connection with Lung Cancer Prognosis.Lung · 2022Review
- Predicting muscle loss during lung cancer treatment (PREDICT): protocol for a mixed methods prospective study.BMJ open · 2021Article
- Sarcopenia is related to poor prognosis in patients after trimodality therapy for locally advanced non-small cell lung cancer.International journal of clinical oncology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purposeSarcopenia is associated with reduced survival in cancer. Currently, data on sarcopenia at presentation and muscle loss throughout treatment are unknown in patients receiving chemoradiation therapy (CRT) for non-small cell lung cancer (NSCLC). This study evaluated skeletal muscle changes in NSCLC patients receiving CRT and relationship with survival.
methodsSecondary analysis of 41 patients with NSCLC treated with CRT assessed for skeletal muscle area and muscle density by computed tomography pre-treatment and 3 months post-treatment. Images at week 4 of treatment were available for 32 (78%) patients. Linear mixed models were applied to determine changes in skeletal muscle over time and related to overall survival using Kaplan-Meier plots.
resultsMuscle area and muscle density decreased significantly by week 4 of CRT (- 6.6 cm
conclusionSignificant loss of muscle area and muscle density occurs in NSCLC patients early during CRT. A high proportion of patients are sarcopenic prior to CRT; however, this was not significantly associated with poorer survival.
Indexed as
Identifiers
30478673What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.