Evidence map›Paper›PMID 30478648›Full record

SynthesisClinical and experimental medicine2019

Associations between the neutrophil-to-lymphocyte and the platelet-to-lymphocyte ratios and the presence and severity of psoriasis: a systematic review and meta-analysis.

Panagiotis Paliogiannis, Rosanna Satta, Giovanni Deligia, Giuseppina Farina, Stefania Bassu, Arduino A Mangoni, Ciriaco Carru, Angelo Zinellu

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical and experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Panagiotis PaliogiannisDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.
Rosanna SattaDepartment of Clinical, Surgical and Experimental Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.
Giovanni DeligiaDepartment of Clinical, Surgical and Experimental Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.
Giuseppina FarinaDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.
Stefania BassuDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.
Arduino A MangoniDepartment of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Ciriaco CarruDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy.
Angelo ZinelluDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100, Sassari, Italy. azinellu@uniss.it.ORCID http://orcid.org/0000-0002-8396-0968

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diagnosis of psoriasis, an immune-mediated disease that affects 2% of the population in Western countries, is largely based on history and clinical examination. The aim of this systematic review and meta-analysis was to investigate the associations between the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and the presence and clinical severity of psoriasis. A systematic literature search was conducted in PubMed, Web of Science, and Scopus, from inception to January 2018. Twelve case-control studies enrolling 1067 psoriasis patients (537 males and 530 females) and 799 healthy controls (404 males and 395 females) were included in the meta-analysis. The NLR was evaluated in all the studies, while the PLR was assessed in four studies. Pooled results showed that both the NLR and the PLR values were significantly higher in patients with psoriasis (SMD = 0.69, 95% CI 0.53-1.85, p < 0.001, and SMD = 0.40, 95% CI 0.12-0.68, p = 0.006, respectively). There were no significant differences in NLR values according to the severity of disease (p = 0.52). The NLR and the PLR are significantly associated with the presence, but not with the severity, of psoriasis. Further studies are required to determine the additional utility of these haematological indexes in the diagnosis of psoriasis.

Indexed as

Decision Support TechniquesAdultFemaleHumansLeukocyte CountMaleMiddle AgedPlatelet CountPsoriasisYoung AdultInflammationLymphocytesNeutrophilsNLRPlateletsPLRPsoriasis

Identifiers

PMID30478648

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.