Evidence map›Paper›PMID 30478521›Full record

ArticleThe AAPS journal2018

Overlooked Issues on Pharmacokinetics Data Interpretation of Protein Drugs-a Case Example of Erythropoietin.

Guohua An, Robert L Schmidt, Donald M Mock, Peter Veng-Pedersen, John A Widness

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The AAPS journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Target-mediated disposition population pharmacokinetics model of erythropoietin in premature neonates following multiple intravenous and subcutaneous dosing regimens.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2019
    Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guohua AnDivision of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, S227 Phar, 115 S. Grand Ave., Iowa City, Iowa, 52242, USA. guohua-an@uiowa.edu.
Robert L SchmidtDepartment of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, USA.
Donald M MockDepartments of Biochemistry and Molecular Biology and Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA.
Peter Veng-PedersenDivision of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, S227 Phar, 115 S. Grand Ave., Iowa City, Iowa, 52242, USA.
John A WidnessDepartment of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, USA.

Funding

THE RoLE OF NEONATAL ANEMIA IN LEARNING AND MEMORYP01HL046925 · NHLBI · UNIVERSITY OF IOWA · PI SOLA-VISNER, MARTHA C. · 1992 to 2022
$34.3M
The University of Iowa Clinical and Translational Science AwardU54TR001356 · NCATS · UNIVERSITY OF IOWA · PI WINOKUR, PATRICIA · 2015 to 2016
$7.1M
NCATS NIH HHS U54 TR001356NHLBI NIH HHS P01 HL046925
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnemiaAnimalsArea Under CurveBiological AssayCHO CellsCricetulusData Interpretation, StatisticalErythropoiesisErythropoietinHematinicsHumansPharmaceutical ResearchRecombinant ProteinsEPO protein, humanErythropoietinHematinicsRecombinant Proteinserythropoietinoverlooked issuespharmacokinetic data interpretationprotein drugs

Identifiers

PMID30478521
PMCPMC7472663

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.