ReviewJournal of nephrology2019
Natural history and risk factors for diabetic kidney disease in patients with T2D: lessons from the AMD-annals.
Review in Journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- The association between poor glycemic control and apical periodontitis: A systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2026Pooled it
- Uric acid in CKD: has the jury come to the verdict?Journal of nephrology · 2020Pooled it
- Glycemic instability in renal decline: a review of HbA1c variability and outcomes in chronic kidney disease.Diabetology & metabolic syndrome · 2026Review
- Vascular Endothelial Growth Factor and Placental Growth Factor in Conjunction with Vascular Endothelial Growth Factor Receptor-1 May Exert Dual Effects Within the Kidney and Brain in Patients with Type 2 Diabetes Mellitus and Normoalbuminuric Diabetic Kidney Disease.International journal of molecular sciences · 2026Article
- Dickkopf-3 (DKK3) and the Progression of Diabetic Kidney Disease in Primary Health Care.Diabetes · 2026Article
- Long-term preservation of kidney function with SGLT-2 inhibitors versus comparator drugs in people with type 2 diabetes and chronic kidney disease.Diabetes, obesity & metabolism · 2025Observational
- Generalizability of kidney and cardiovascular protection by finerenone to the real world in Italy: insights from Fidelio and Figaro studies.Journal of nephrology · 2025Article
- Multifaceted relationship between diabetes and kidney diseases: Beyond diabetes.World journal of diabetes · 2023Review
- Redox regulation in diabetic kidney disease.American journal of physiology. Renal physiology · 2023Review
- High levels of serum C-peptide are associated with a decreased risk for incident renal progression in patients with type 2 diabetes: a retrospective cohort study.BMJ open diabetes research & care · 2023Article
- Urinary Markers of Tubular Injury and Renal Fibrosis in Patients with Type 2 Diabetes and Different Phenotypes of Chronic Kidney Disease.Life (Basel, Switzerland) · 2023Article
- Non-albuminuric Diabetic Kidney Disease Phenotype: Beyond Albuminuria.TouchREVIEWS in endocrinology · 2022Review
- Plasma activity of the antioxidant enzymes in predicting diabetic nephropathy progression.International urology and nephrology · 2022Article
- Risk Factors for Progression of CKD with and without Diabetes.Journal of diabetes research · 2022Article
- Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency.European journal of medical research · 2021Review
- Association between anemia and mortality in hemodialysis patients is modified by the presence of diabetes.Journal of nephrology · 2021Article
- Gender Differences in Diabetic Kidney Disease: Focus on Hormonal, Genetic and Clinical Factors.International journal of molecular sciences · 2021Review
- Variability of risk factors and diabetes complications.Cardiovascular diabetology · 2021Review
- Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications.Cardiovascular diabetology · 2021Review
- Blood pressure reduction and RAAS inhibition in diabetic kidney disease: therapeutic potentials and limitations.Journal of nephrology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Associazione Medici Diabetologi (AMD) annals initiative is an ongoing observational survey promoted by AMD. It is based on a public network of about 700 Italian diabetes clinics, run by specialists who provide diagnostic confirmation and prevention and treatment of diabetes and its complications. Over the last few years, analysis of the AMD annals dataset has contributed several important insights on the clinical features of type-2 diabetes kidney disease and their prognostic and therapeutic implications. First, non-albuminuric renal impairment is the predominant clinical phenotype. Even though associated to a lower risk of progression compared to overt albuminuria, it contributes significantly to the burden of end-stage renal disease morbidity. Second, optimal blood pressure control provides significant but incomplete renal protection. It reduces albuminuria but there may be a J curve phenomenon with eGFR at very low blood pressure values. Third, hyperuricemia and diabetic hyperlipidemia, namely elevated triglycerides and low HDL cholesterol, are strong independent predictors of chronic kidney disease (CKD) onset in diabetes, although the pathogenetic mechanisms underlying these associations remain uncertain. Fourth, the long-term intra-individual variability in HbA1c, lipid parameters, uric acid and blood pressure plays a greater role in the appearance and progression of CKD than the absolute value of each single variable. These data help clarify the natural history of CKD in patients with type 2 diabetes and provide important clues for designing future interventional studies.
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