Evidence map›Paper›PMID 30478475›Full record

ArticleCancer immunology, immunotherapy : CII2019

Can benign lymphoid tissue changes in

Christos Sachpekidis, Lionel Larribère, Annette Kopp-Schneider, Jessica C Hassel, Antonia Dimitrakopoulou-Strauss

Open access · greenAbstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. The value ofEuropean journal of nuclear medicine and molecular imaging · 2021
    Pooled it
  2. Pooled it
  3. [European journal of nuclear medicine and molecular imaging · 2026
    Review
  4. Article
  5. Article
  6. Can physiologic colonic [European journal of nuclear medicine and molecular imaging · 2023
    Article
  7. Review
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  11. Joint EANM/SNMMI/ANZSNM practice guidelines/procedure standards on recommended use of [European journal of nuclear medicine and molecular imaging · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Immune PET Imaging.Radiologic clinics of North America · 2021
    Review
  17. Article
  18. Quantitative DynamicCancers · 2021
    Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Christos SachpekidisClinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany. christos_saxpe@yahoo.gr.
Lionel LarribèreSkin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Annette Kopp-SchneiderDepartment of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jessica C HasselDepartment of Dermatology and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.
Antonia Dimitrakopoulou-StraussClinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Germany.
German Cancer Research Center · DEHeidelberg University · DEUniversity Medical Centre Mannheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn association between immune-related adverse events (irAEs) caused by immunotherapeutic agents and the clinical benefit of immunotherapy has been suggested. We retrospectively evaluated by means of

methodsA total of 41 patients with unresectable metastatic melanoma underwent

resultsAccording to the BCR reference, 31 patients showed disease control (DC) and 10 patients showed progressive disease (PD). Mediastinal/hilar lymph node evaluation revealed that in total 4 patients in the interim or late PET/CT (10%) demonstrated a 'sarcoid-like lymphadenopathy' as response to treatment (LN-positive). All LN-positive patients responded to ipilimumab with DC. On the other hand, no significant differences between the DC and PD groups regarding both semi-quantitative and quantitative

conclusionBased on our findings, 10% patients in the interim or late PET/CT showed 'sarcoid-like lymphadenopathy' as response to treatment. All these patients showed disease control, implying a relation between the appearance of sarcoid-like lymphadenopathy and the clinical benefit of anti-CTLA-4 therapy. On the other hand, quantitative

Indexed as

Antineoplastic Agents, ImmunologicalFemaleFluorodeoxyglucose F18HumansImmunotherapyIpilimumabLymphoid TissueMaleMelanomaMiddle AgedNeoplasm MetastasisPositron Emission Tomography Computed TomographyPrognosisRetrospective StudiesAntineoplastic Agents, ImmunologicalFluorodeoxyglucose F18Ipilimumab18F-FDG PET/CTIpilimumabMetastatic melanoma‘Sarcoid-like lymphadenopathy’Spleen glucose metabolism

Identifiers

PMID30478475
PMCPMC11028352
OpenAlexW2903343893

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.