ArticleNature immunology2019
Macrophage de novo NAD
Open access · greenAbstract read
In one paragraph
Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 311 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
311citing papers in PubMed, 1 pooled it
11.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
311 citing papers in PubMed, 1 synthesis or guideline pooled it, 500 citations in OpenAlex.
- A comprehensive analysis of the role of QPRT in breast cancer.Scientific reports · 2023Pooled it
- Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial.Nature medicine · 2026Trial
- Changes in ultraviolet a radiation-induced thymidine dimers and erythema after oral nicotinamide or polypodium leucotomos extract in healthy volunteers: a randomized intraindividual trial.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Trial
- Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial.Nature aging · 2024Trial
- Article
- SIRT1 Inhibits T-cell Infiltration and Tertiary Lymphoid Structure Formation to Promote Radioimmunotherapy Resistance.Cancer research · 2026Article
- Nicotinamide Mononucleotide Attenuates Inflammatory Activation, Choroidal Neovascularization, and Lesion-Associated Remodeling.Investigative ophthalmology & visual science · 2026Article
- SIRT6-Mediated Deacetylation of ATF3 Promotes Silica-Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation.Cell death and differentiation · 2026Article
- Age-Associated Senescence of Decidual Macrophages: A Key Mediator of Adverse Pregnancy Outcomes in Advanced Maternal Age.Aging cell · 2026Article
- Review
- Metabolically engineered probiotic OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy.Cell reports. Medicine · 2026Article
- Sphingosine kinase-2 inhibition promotes immunogenic differentiation of myeloid-derived suppressor cells through an Acetyl-CoA carboxylase-phosphatidylcholine axis.Nature communications · 2026Article
- Senescent BMSC-Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin-Mediated Mitophagy in Macrophages.Aging cell · 2026Article
- Ion-coupled transfersome complexes for enhanced transdermal NADMaterials today. Bio · 2026Article
- A metabolic constraint in de novo NAD+ synthesis drives mucosal inflammation in IBD.Journal of Crohn's & colitis · 2026Article
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- Tryptophan pathway metabotypes associate with disease activity and immune-metabolic dysfunction in inflammatory bowel disease.medRxiv : the preprint server for health sciences · 2026Article
- Intracellular NADJournal of cellular and molecular medicine · 2026Article
- Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo.Advanced functional materials · 2026Article
251 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 1 country.
Paras S MinhasDepartment of Neurology & Neurological Sciences, Stanford School of Medicine, Stanford, CA, USA.
Ling LiuLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Peter K MoonDepartment of Neurology & Neurological Sciences, Stanford School of Medicine, Stanford, CA, USA.
Amit U JoshiDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2472-7672
Christopher DoveDepartment of Hematology, Stanford School of Medicine, Stanford, CA, USA.
Siddhita MhatreDepartment of Neurology & Neurological Sciences, Stanford School of Medicine, Stanford, CA, USA.
Kevin ContrepoisDepartment of Genetics, Stanford School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9678-5161
Qian WangDepartment of Neurology & Neurological Sciences, Stanford School of Medicine, Stanford, CA, USA.
Brittany A LeeDepartment of Genetics, Stanford School of Medicine, Stanford, CA, USA.
Michael CoronadoDepartment of Pediatrics, Stanford School of Medicine, Stanford, CA, USA.
Daniel BernsteinDepartment of Pediatrics, Stanford School of Medicine, Stanford, CA, USA.
Michael P SnyderDepartment of Genetics, Stanford School of Medicine, Stanford, CA, USA.
Marie MigaudMitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
Ravindra MajetiDepartment of Hematology, Stanford School of Medicine, Stanford, CA, USA.
Daria Mochly-RosenDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6691-8733
Joshua D RabinowitzLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Katrin I AndreassonDepartment of Neurology & Neurological Sciences, Stanford School of Medicine, Stanford, CA, USA. kandreas@stanford.edu.ORCID http://orcid.org/0000-0001-8391-4155
Stanford Medicine · USPrinceton University · USStanford University · USNeurosciences Institute · USUSA Mitchell Cancer Institute · US
Funding
Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4MWorking Memory in Parkinson Disease: A Cognitive & Systems Neuroscience ApproachP50AG047366 · NIA · STANFORD UNIVERSITY · PI HENDERSON, VICTOR · 2015 to 2019
$7.9MMetabolism in Action: Quantitative Fluxes in MammalsDP1DK113643 · NIDDK · PRINCETON UNIVERSITY · PI RABINOWITZ, JOSHUA D · 2016 to 2020
$5.7MMechanisms of Ethanol-Induced Cardiac ProtectionR37AA011147 · NIAAA · STANFORD UNIVERSITY · PI MOCHLY-ROSEN, DARIA · 2009 to 2018
$5.3MTraining in Myocardial Biology at Stanford (TIMBS)T32HL094274 · NHLBI · STANFORD UNIVERSITY · PI Euan A Ashley, Daniel Bernstein · 2010 to 2026
$5.0MTargeting the kynurenine pathway in Alzheimer's diseaseR01AG048232 · NIA · STANFORD UNIVERSITY · PI ANDREASSON, KATRIN I. · 2014 to 2018
$2.4MRegulation of immune cell metabolism in aging and Alzheimer's disease: role of the kynurenine pathwayRF1AG058047 · NIA · STANFORD UNIVERSITY · PI ANDREASSON, KATRIN I. · 2017 to 2017
$2.0MPre-Leukemic Hematopoietic Stem Cells and Clonal Evolution in Human AMLR01CA188055 · NCI · STANFORD UNIVERSITY · PI MAJETI, RAVINDRA · 2014 to 2018
$1.6MStanford Career Development Program in Omics of Lung DiseasesK12HL120001 · NHLBI · STANFORD UNIVERSITY · PI NICOLLS, MARK ROBERT, RABINOVITCH, MARLENE · 2013 to 2017
$1.3MBeta-adrenergic signaling modulates mitochondrial function and dynamicsR00HL129474 · NHLBI · WHITMAN COLLEGE · PI CORONADO, MICHAEL J. · 2018 to 2020
$747kBeta-adrenergic signaling modulates mitochondrial function and dynamicsK99HL129474 · NHLBI · STANFORD UNIVERSITY · PI CORONADO, MICHAEL J. · 2015 to 2016
$296kNCI NIH HHS P30 CA124435NCI NIH HHS R01 CA188055NHLBI NIH HHS K12 HL120001NHLBI NIH HHS K99 HL129474NHLBI NIH HHS R00 HL129474NHLBI NIH HHS T32 HL094274NIAAA NIH HHS R37 AA011147NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG048232NIA NIH HHS RF1 AG058047NIDDK NIH HHS DP1 DK113643NIH HHS 1P50 AG047366NIH HHS 1S10RR02678001NIH HHS 5R01CA188055NIH HHS 5T32HL094274NIH HHS 5U54DK10255603NIH HHS R37 AA11147NIH HHS RF1AG058047NIH HHS RO1AG048232
Abstract
Recent advances highlight a pivotal role for cellular metabolism in programming immune responses. Here, we demonstrate that cell-autonomous generation of nicotinamide adenine dinucleotide (NAD
Indexed as
AgingAnimalsCells, CulturedHomeostasisImmunity, InnateIndoleamine-Pyrrole 2,3,-DioxygenaseInflammationKynurenineMacrophagesMiceMice, Inbred C57BLMice, KnockoutMitochondriaNADNicotinate-Nucleotide Diphosphorylase (Carboxylating)Oxidative PhosphorylationIDO1 protein, mouseIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineNADNicotinate-Nucleotide Diphosphorylase (Carboxylating)PentosyltransferasesTryptophan
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.